Background: Alzheimer’s, the predominant formof dementia, is a neurodegenerative brain disorder with no known cure. With the lack of innovative findings to diagnose and treat Alzheimer’s, the number of middle-aged people with dementia is estimated to hike nearly to 13 million by the end of 2050. The estimated cost of Alzheimer’s and other related ailments is USD321 billion in 2022 and can rise above USD1 trillion by the end of 2050. Therefore, the early prediction of such diseases using computer-aided systems is a topic of considerable interest and substantial study among scholars. The major objective is to develop a comprehensive framework for the earliest onset and categorization of different phases of Alzheimer’s. Methods: Experimental work of this novel approach is performed by implementing neural networks (CNN) on MRI image datasets. Five classes of Alzheimer’s disease subjects are multi-classified. We used the transfer learning determinant to reap the benefits of pre-trained health data classification models such as the MobileNet. Results: For the evaluation and comparison of the proposed model, various performance metrics are used. The test results reveal that the CNN architectures method has the following characteristics: appropriate simple structures that mitigate computational burden, memory usage, and overfitting, as well as offering maintainable time. The MobileNet pre-trained model has been fine-tuned and has achieved 96.6 percent accuracy for multi-class AD stage classifications. Other models, such as VGG16 and ResNet50 models, are applied tothe same dataset whileconducting this research, and it is revealed that this model yields better results than other models. Conclusion: The study develops a novel framework for the identification of different AD stages. The main advantage of this novel approach is the creation of lightweight neural networks. MobileNet model is mostly used for mobile applications and was rarely used for medical image analysis; hence, we implemented this model for disease detection andyieldedbetter results than existing models.