Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microenvironment in mesothelioma is likely contributing to this therapy resistance. Therefore, it is important to explore the characteristics of the tumor microenvironment for explanations for this recalcitrant behavior. This review describes the stromal, cytokine, metabolic, and cellular milieu of mesothelioma, and attempts to make connection with the outcome of immunotherapy trials.

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In this paper, a generalized approach for the systematic generation of robust control rules for the boost power factor correction converter is presented. Based on a cascading multiloop control structure, a unified approach for deriving the control functions for the inner current loop and the outer voltage loop is proposed. The resulting control provides unity power factor and regulated average output voltage with fast transient response. The control performance is robust under all practical conditions as a result of the application of feedback linearization. This method eliminates the nonlinearity and the dependence of the error dynamics on the input disturbance. The control parameters can be designed according to the desired steady-state and transient response performances. The resulting control rules are readily implemented in analog circuitries. Experiments are conducted to evaluate the control performance.Index Terms-AC-DC power conversion, power electronics, power quality, power supplies, power system control.