Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3 gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences and small flip angles ( < 10 degrees). Thick-section (20 mm) coronal images, time-course data (30 images collected every 1.8 seconds), and thin-section (6 mm) images were acquired. Subjects were able to breathe the gas (12% polarization) without difficulty. Thick-section images were of good quality and had a signal-to-noise ratio (S/N) of 32:1 near the surface coil and 16:1 farther away. The time images showed regional differences, which indicated potential value for quantitation. High-resolution images showed greater detail and a S/N of approximately 6:1.

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The distribution of iron in the brain was analyzed using high field strength (1.5 T) magnetic resonance (MR) imaging in 14 healthy control individuals and six patients with Parkinson plus syndromes (multisystem atrophy and progressive supranuclear palsy) who were unresponsive to antiparkinsonian therapy. The normal topographic distribution of iron in the brain as indicated by high field MR images coincided precisely with the distribution of iron in the brain as determined by Perls staining for ferric iron. In Parkinson plus syndromes, there were abnormally increased concentrations of iron (decreased T2 relaxation times) in the putamen, and less prominent increases in the caudate nucleus and lateral pars compacta of the substantia nigra. In high field strength MR images of normal patients, the decreased signal intensity in the globus pallidus is more prominent than that of the putamen. In MR images of patients with Parkinson plus syndromes, the decreased signal intensity of the putamen is more prominent than that of the globus pallidus.

We describe an experimental study of porous media convection (PMC) from onset to 8Ra c . The goal of this work is to provide non-invasive imaging and high-precision heat transport measurements to test theories of convection in PMC. We obtain velocity information and visualize the convection patterns using magnetic resonance imaging (MRI). We study both ordered and disordered packings of mono-disperse spheres of diameter d = 3.204 ± 0.029 mm, in circular, rectangular, and hexagonal planforms. In general, the structure of the medium plays a role which is not predicted by theories which assume a homogeneous system. Disordered media are prepared by pouring mono-disperse spheres into the container. Large ordered regions of close packing for the spheres, with grain boundaries and isolated defects, characterize these media. The defects and grain boundaries play an important role in pattern formation in disordered media. Any deviation from close packing produces a region of larger porosity, hence locally larger permeability. The result is spatial variations in the Rayleigh number, Ra. We define the critical Ra, Ra c , as the Rayleigh number at the onset of convection in the ordered regions. We find that stable localized convective regions exist around grain boundaries and defects at Ra < Ra c . These remain as pinning sites for the convection patterns in the ordered regions as Ra increases above Ra c up to 5Ra c , the highest Ra studied in the disordered media. In ordered media, spheres are packed such that the only deviations from close packing occur within a thin (