Grace P. Li scite author profile

Oxygenation of pioglitazone-7V-oxide by a microorganism isolated from soil was accompanied by iV-deoxygenation to produce the pioglitazone metabolites 5-[4-[2-[5-(l-hydroxyethyl)-2pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione and 5-[4-[2-(5-acetyl-2-pyridyl)ethoxy]benzyl]-2,4thiazolidinedione. The oxygenating/deoxygenating organism has been characterized as Streptomyces hygroscopicus strain 02179 (UC 1 1099). The culture has been deposited with Agricultural Research Service, USDA,with accession number NRRL18975.

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Grace P. Li

Isolation and identification of 7,8-didemethyl-8-hydroxy-5-deazariboflavin, an unusual cosynthetic factor in streptomycetes, from Streptomyces lincolnensis.

Discovery, production, and biological assay of an unusual flavenoid cofactor involved in lincomycin biosynthesis.

Microbiological N-Deoxygenation and C-Oxygenation of Pioglitazone-N-oxide in a Single Fermentation.

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