No abstract

A mild and practically-convenient one-pot procedure for the direct beta-substitution of enones has been developed using a conjugate addition-oxidation strategy with a full range of copper-based reagents and N-tert-butylphenylsulfinimidoyl chloride; alkyl- and aryl-substituted enones are delivered in good to excellent yields.

Reactions of organo-metal compounds O 0350Highly Efficient Methods for the One-Pot Synthesis of β-Substituted Enones. -The one-pot procedure consists of a conjugate addition-oxidation sequence and is applicable to both cyclic and acyclic enones. Various organocuprate reagents can be used for the first step. Best yields are observed with simple Gilman cuprates. -(KERR*, W. J.; PEARSON, C. M.; THURSTON, G. J.; Org.