Among the most feared toxico-dermas is drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, a rare drug dermatitis that occurs after acute exposure to drugs whose clinical impact is based on multiple organs (skin, liver, kidneys, lungs, heart) and cell lines (eosinophils and lymphocytes). It is an entity with high mortality if it is not identified early, its treatment consists of the immediate suspension of the responsible drug and the administration of steroids, these being the therapeutic protagonists. A 64-year-old male patient with clinical, biochemical and histopathological criteria compatible with DRESS syndrome. It is essential to suspect the clinical course of DRESS syndrome before the appearance of dermatosis with multisystem involvement associated with the use of drugs, emphasis is placed on its early identification and the establishment of timely treatment to modify its prognosis.

Kaposi's sarcoma (KS) is a malignant vascular neoplasm that typically appears opportunistically in patients with acquired immunodeficiency syndrome (AIDS); it can also arise in organ transplanted subjects and exceptionally in carriers of autoimmune diseases, such as Behçet's disease. A 23-year-old man with Behçet's disease who debuts with clinically and histologically compatible dermatosis with KS. Conclusions. KS is not exclusive to HIV-AIDS, it also prevails in situations of primary or secondary immunocompromision that favor its appearance, as is the case of Behçet's Disease and its immunomodulatory therapy.