The data show worsening of K-D test scores following concussion further supporting utility of the K-D test as an objective, reliable and effective sideline visual screening tool to help identify athletes with concussion.

A 2010 NIH forum investigated how barriers to collaboration among academia, government, and industry must be identified and overcome to maximize the clinical return on investment in science (see also the five accompanying meeting reports).

Background: The use of radioprotectors and radiomitigators could improve the therapeutic index of radiation therapy. With the intention of accelerating translation of radiation-effect modulators (radioprotectors and mitigators), the Radiation Research Program (RRP) and SBIR (Small Business Innovation Research) Development Center within the National Cancer Institute (NCI) issued four Requests for Proposals (RFPs) from 2010 to 2013. Twelve SBIR contract awards in total were made in response to the four RFPs from September 2011 through September 2014. Here, we provide an update on the status of SBIR contract projects for the development of radiation-effect modulators. Methods: To assess the status of research and development efforts under the four RFPs on radiation-effect modulators, we searched PubMed for research articles, google.com for published abstracts, clinicaltrials.gov for ongoing or completed clinical trials, and company websites for press releases and other news. All information obtained and reported here are publicly available and hence protect the intellectual property of the investigators and companies. Results: Of the 12 SBIR projects funded, 5 (42%) transitioned successfully from Phase I to Phase II SBIR funding, and among the Fast-Track contracts, this rate was 100% (3/3). The internet search identified 3 abstracts and 6 publications related to the aims of the SBIR contracts. One-third of the companies (4/12) have successfully launched a total of 8 clinical trials to demonstrate the safety and efficacy of their investigational agents. Two drugs are in clinical trials for their