We experimentally investigate Raman optical activity in the scattering of light with spin and orbital angular momentum. Varying combinations of spin and orbital angular momentum of light, associated with circular polarization and the helical phase structure of Laguerre-Gaussian modes, respectively, are generated by transforming a cylindrical vector beam into a circular polarized Laguerre-Gaussian mode. Raman back scattered light of a circular polarized Laguerre-Gaussian beam propagating along the optic axis of a c-cut uniaxial birefringent quartz sample is collected with a spectrometer. The resulting Stokes shifted spectra is analyzed and discussed in relation to traditional Raman optical activity.