Aim There is increasing interest in using collimated gamma cameras for [75Se]tauroselcholic acid (SeHCAT) studies to image the distribution and to make use of the collimator pressure sensitive devices (PSD) for patient safety. However, the use of a collimator will substantially decrease the sensitivity of the gamma camera. The aim of this article is to enable departments to calculate the uncertainty of SeHCAT retention measurements so that the acquisition time can be optimised to perform a reliable SeHCAT study. Method We derive a mathematical equation from the first principles that can be used to calculate the uncertainty in SeHCAT retention measurements on the basis of Poisson counting statistics. The equation takes account of background subtraction, use of the geometric mean for anterior/posterior attenuation compensation and the day 7 to day 0 quotient calculation. Results Uncertainties in SeHCAT retention measurement using an intrinsic (uncollimated) gamma camera counting for 100 s are very low, typically of the order 15 ± 0.1%. Uncertainties from collimated gamma camera counting significantly increase for the same 100 s counting duration: 15 ± 0.8% for slim patients and 15 ± 4% for obese patients. Conclusion The acquisition time must be increased for collimated gamma camera SeHCAT counting to achieve acceptable counting statistics for an acceptable total uncertainty in the SeHCAT retention measurement. For slim patients, a minimum counting time of 2 min is required. For larger patients, the acquisition time needs to be increased to 30 min and further increased to 50 min for obese patients.
A transmission line allows different frequencies to conduct alternating current (AC). They are a peculiar type of wire that allows signal transmission while making it resistant to external noises. A parallel-plate transmission line is a type of transmission line designed with two parallel plates with a dielectric sheet material in the center, as the name implies. The parallel-plate transmission lines are usually used for a miniature setup in which the line prevents the signal from losing power. However, the line's frequency response is a varying setup in which a change in a parameter can fully change the frequency response of the line, and in turn trigger inefficiency. With this, different factors such as the conductor, the size, and the dielectric material of the parallel-plate transmission line can affect its frequency response. Specifically, the analysis of the transmission would test the various frequency responses when the dielectric sheet content is varied. The researchers will carry out experiments on air, Teflon, plexiglass, and E type glass dielectrics.
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