Background/Objectives: Gastrointestinal phenotypes have previously been associated with obesity, however it is unknown if these phenotypes are a cause or a consequence of obesity and weight gain. Our aim was to assess whether these gastrointestinal phenotypes are associated with future weight gain in younger adults. Subjects/Methods: At baseline, 126 adult participants under the age of 35 were weighed and underwent measurement of gastrointestinal phenotypes including gastric emptying (GE), gastric volume, satiation, satiety and gastrointestinal hormones. Patients were re-appraised after median 4.4 years unless, during the period of follow up, they participated in a formal weight loss program, received obesity-weight loss interventions, or developed a health condition likely to affect weight. Participants were dichotomized into two groups for each phenotype at the median of each phenotype. Results: In total, 60 participants met criteria for inclusion and were evaluated after a median of 4.4 years [IQR: 3.5 to 5],36 participants were excluded due to conditions that would abnormally affect weight during study period including pregnancy and weight loss treatment, and 30 participants were lost to prospective follow-up. Faster GE was significantly associated with weight gain. Those with faster GE at baseline (n=30) gained a median of 9.6 kg [3.1 to 14.9] compared to those with slower GE at baseline (n=30) who gained a median of 2.8 kg [−4.6 to 9.2] (p=0.03), over the follow-up period. There was no association between the other phenotypes and weight gain. Conclusions: In adults ≤35 years old, faster gastric emptying is associated with significantly increased weight gain over the medium term. This provides supportive evidence for the role of gastric emptying in weight gain and development of obesity.

Purpose of review Endoscopic bariatric therapy (EBT) is a rapidly developing area that has now seen FDA approval of six endoscopic bariatric devices and procedures and there are a number of other novel EBTs progressing through various stages of development with newly published findings. This paper aims to assist readers in either selecting an appropriate therapy for their patient or deciding to incorporate these therapies into their practice. This paper provides an updated review of the available data on EBTs, both FDA approved and not, with a particular focus on effectiveness and safety, as well as guidance for discussing with your patient the decision to use endoscopic therapies. Findings The authors of a large meta-analysis of Orbera concluded its ideal balloon volume to be 600-650 mL. AspireAssist has had favorable effectiveness and safety data published in a large RCT. A large study of endoscopic sleeve gastroplasty has published findings at up to 24 months showing promising durability. Elipse, a swallowed intragastric balloon not requiring endoscopy for either insertion or removal, has had early favorable results published. A magnet-based system for creation of a gastrojejunostomy has published favorable findings from its pilot study. Summary EBTs are safe and effective therapies for weight loss when used in conjunction with lifestyle changes and fill an important gap in the management of obesity. There are now six FDA-approved EBTs available and several more in ongoing trials with favorable early findings. More study is needed to understand the role of EBTs used in combination or in sequence with medications and bariatric surgery.

A 71-year-old woman with a history of diverticulosis presented to the emergency department with left lower quadrant pain for 2 days rated 10 of 10. She had a fever of 38.1°C and a leukocytosis of 12.8 k/mm 3 . A computed tomography scan revealed sigmoid diverticula, focal wall thickening, fat stranding, and a linear hyperdensity in the sigmoid colon (Figure 1). She was started on antibiotics and admitted for the management of diverticulitis and pain. Concern for a possible foreign body evidenced by the linear hyperdensity drove the decision to proceed with colonoscopy. On colonoscopy, a chicken bone was found impacted in a sigmoid colon diverticulum with surrounding inflammation (Figures 2 and 3). It was successfully removed with a rat tooth forceps without complications or subsequent signs of mucosal perforation (Figure 4). Her symptoms improved, and she was discharged with oral antibiotics. She did not recall ingesting the bone.Acute diverticulitis is normally a contraindication to colonoscopy because of risk of perforation. 1 However, in this instance when the precipitant of inflammation is a foreign body, a colonoscopy can be cautiously attempted for removal.

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