ritical illness can lead to hypermetabolism and subsequent malnutrition. 1,2 Malnutrition is strongly associated with increased morbidity and mortality rates among seriously ill patients. 3,4 Thus, standards of care for patients with critical illness include nutritional support. Recent reviews suggest that enteral nutrition (EN) is associated with lower septic morbidity rates and that parenteral nutrition (PN) may be associated with increased rates of complications and death. 5-7 Immune-enhancing diets may be beneficial for elective surgical patients but have no benefit and may harm the critically ill patient. 6 If EN is preferable, starting sooner may be better. Data from the few animal and clinical studies on this topic support this hypothesis. 7 However, recent observational studies have documented low rates of "optimal" use of EN in the critical care setting. 8-10 EN is often started several days after admission, patients do not tolerate adequate amounts of EN, and PN is used excessively in some patients (up to 60% in some countries). 8-10 Using an audit of intensive care units (ICUs) in community and teaching hospitals, our Critical Care Research Network (CCR-Net) also documented delays in the institution of nutritional support that included both enteral and parenteral routes. 11 Several studies have shown that using nurse-directed feeding protocols or algorithms increases the amount of EN delivered daily 12,13 and that enhancing delivery may improve outcomes in some patients. 14 Protocols may improve this process. We report a prospective, cluster-randomized clinical trial in the ICUs of community and teaching hospitals that tested the hypothesis that an evidence-based algorithm for nutritional support in critically ill patients, accompanied by a multifaceted implementation strategy, would improve the provision of nutritional support and patient outcomes. Methods The study consisted of a run-in phase followed by cluster randomization of hospitals to the intervention or control group. Cluster randomization reduces the risk of contamination between groups, but individual patient characteristics can still be evaluated by appropriate analysis. 15 Patient enrolment into both phases of the study occurred from October 1997 to September 1998. Patients were included if they were at least 16 years of age and were expected to stay in the ICU at least 48 hours. Patients were excluded if they were expected to be receiving sufficient nutrition orally to meet their daily energy requirements within 24 hours after ICU admission, were admitted for palliative care, were moribund and not expected to survive for more than 6 hours, or were suspected to be brain dead. The Ethics Review Board at the University of Western Ontario waived the requirement for informed consent on the basis that the intervention was a quality-improvement initiative. The study was conducted in 11 community and 3 teaching hospitals in Ontario. All hospitals that volunteered for the study were Multicentre, cluster-randomized clinical trial of algorithms for...

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RationaleWe completed a 1,118 patient cluster randomised trial of evidence−based guidelines (EBG) for nutrition support in critical illness. The EBG resulted in significant improvements in nutritional support and a reduction in clinically significant renal dysfunction (RD) (1.54 vs 2.12 RD days per 10 patient•days, p=0.038). This exploratory post−hoc analysis investigates renal outcomes in a subgroup of patients at high risk of acute renal failure (ARF). MethodsHigh risk of ARF was defined as creatinine increase by > 20% at study entry, to at least 1.36 mg/dL, compared to last known pre−enrolment levels in the presence of a known risk factor for ARF. P−values were adjusted for clustering. Results are considered hypothesis generating. Results 242 high risk patients were identified (128/561 EBG vs 114/557 control, p=0.60). 63% were males, average age was 64, and APACHE II was 27. There was no baseline imbalance. EBG patients received more nutritional support (8.0 vs 6.5 days per 10 day stay, p=0.009), with a trend towards higher protein (48 vs 37 gm/day, p=0.074) and calorie (1270 vs 980 kcals per day, p=0.083) intake. There was no difference in the proportion of patients experiencing RD (73% vs 82%, p=0.137), but RD was shorter in EBG patients (3.8 vs 5.6 RD days per 10 patient•days, p=0.009). Significantly fewer EBG patients required renal replacement therapy (RRT) (33% vs 46%, p=0.028) however the duration of RRT did not differ (2.0 vs 2.3 RRT days per 10 patient•days, p=0.642). ConclusionsIn animal models, infusions of amino acids can ameliorate the severity of ischemic ARF and enhance renal cell regeneration. Our findings suggest protein intake in critical illness may reduce the severity of renal dysfunction and need for RRT. Future trials with greater power should investigate this relationship. This abstract is funded by: ANZIC Foundation.

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