Abstract. The laccase of 4222 produced was investigated to the degradation ability of lignin and cellulose in the corn stalk powder solid Medium. The results showed that laccase peak was lat er than the liquid culture, arrived 1842.9 U/L on 15d. The training period of 30d, weight loss of powder dry straw was 82.48%, the lignin of 83.57% and the cellulose of 86.85% is degraded. 4222 has well ability to degrade of corn stove, and it is as a good candidate for lignin degradation.