Objective: To study the relationship between the meridian and diseases by establishing a pathological model and study the effects of blocked channels on the behavior of mini-pigs.Method: First, we measured the low electrical impedance line along the stomach meridian. Next we measured the hydraulic resistance (HR) around the meridian to find points with the lowest HR. Gel were then injected into the points to establish a model for "blocked meridian". A control group was injected with saline. The behaviors of the mini-pigs were observed. The video was then reviewed and frequency of climbing fence in the dtime (FCFD) and frequency of nighttime activity (FNA) were analyzed. Results:When the mean values in various time periods were compared, there was no significant difference between the two groups in the two markers. However, over time, the model group exhibited an upward trend of FCFD which had a correlation coefficient of 0.868 with the modeling ds, i.e. the ds elapsed after establishing the model which was statistically significant. The control group, was -0.045, which was not statistically significant. There was a similar tendency for FNA over time that the correlation coefficient between FNA and modeling ds was 0.675 (P<0.1) while it was 0.401 in the control group (P>0.1). Conclusion:Blocking LHRC along stomach meridian produces behavioral changes that are consistent with the pathological symptoms of stomach meridian. These changes are directly correlated with the modeling ds and gradually become more pronounced with the passage of time.