OBJECTIVE:To provide a meta-analyisis on whether obesity could be a prognostic indicator on the severity, development of complications and mortality of acute pancreatitis (AP). METHODS:Eligible articles were retrieved using electronic databases. Clinical studies evaluating the association between obesity and disease course of patients with AP were included. Weighted mean difference (WMD) and 95% confidence interval (CI) were estimated and pooled using RevMan 4.2.8. RESULTS:In all, 12 clinical studies with a total of 1483 patients were included in the analysis. Obese patients had a significantly increased risk of severe acute pancreatitis (SAP; RR = 2.20, 95% CI 1.82-2.66, P < 0.05), local complication (RR = 2.68, 95% CI 2.09-3.43, P < 0.05), systemic complication (RR = 2.14, 95% CI 1.42-3.21, P < 0.05) and in-hospital mortality (RR = 2.59, 95% CI 1.66-4.03, P < 0.05) compared with non-obese patients. CONCLUSIONS:Obesity is a definite risk factor of morbidity and in-hospital mortality for AP and may serve as a prognostic indicator.KEY WORDS: acute pancreatitis, body mass index, obesity, meta-analysis.

To knock down APE1/Ref-1 gene expression may significantly sensitize the SW1990 cells to gemcitabine and enhance cell apoptosis.