To determine whether parenteral L-arginine supplementation enhances the impaired wound healing of rats subjected to trauma/hemorrhagic shock. Impaired wound healing after trauma and shock has been documented experimentally and clinically. L-arginine has been shown to enhance wound strength and collagen synthesis in rodents and humans. Its efficacy under conditions of impaired wound healing is less well defined. Forty-eight male Lewis rats were used in this study. Using a well-defined model, 24 rats underwent trauma/hemorrhagic shock before wounding. Twenty-four untreated rats served as controls. All animals underwent a dorsal skin incision with implantation of polyvinyl-alcohol sponges. Half of the animals in each group were assigned to receive 1 g/kg/day of L-arginine by intraperitoneal injection in three divided doses, while the other half received saline injections only. Animals were sacrificed 10 days postwounding, and wound-breaking strength (WBS) and wound sponge total hydroxyproline (OHP) and nitrite/nitrate (NO(x)) content were determined. Wound sponge RNA was collected and subjected to Northern blot analysis for procollagens I and III. Trauma/hemorrhage greatly decreased WBS with a concomitant diminution in collagen (OHP) deposition. L-arginine significantly enhanced WBS (19%) and increased OHP (21%) levels in control animals as well as in rats subjected to trauma/hemorrhage (WBS +29%, OHP 40%) compared with their saline-treated counterparts. Procollagen I and III mRNA levels were elevated by L-arginine treatment in both trauma/hemorrhage and control rats. Arginine treatment had no effect on wound fluid and plasma NO(x). The data demonstrate that the impaired healing subsequent to trauma/hemorrhage can be greatly alleviated by L-arginine supplementation.
Water contamination events of urban water supply often show the characteristics of abruptness and variety, and the on-line water quality monitoring parameters usually are difficult to cover various contaminant parameters. With the help with routine detection and on-line water quality monitoring, it is possible to detect and judge whether a water quality event has happened or not and to identify its type indirectly, and obtain the relevant information of qualitative and quantitative analysis. These will be significant to the decision making by the concerning sectors and units. Taking the events of ammonium iron sulfate in the distribution system for example, the relationship of water between contamination concentration and conventional water quality monitoring parameters is investigated, and the quantitative method based on D-S evidence theory is given.
The flexibility and instantaneity of existing water environment warning system seems difficult to satisfy the increasingly severe water environment security situation and water pollution events. A dynamic early warning system structure based on pollutant dispersion simulation has been put forward, with some research on the construction of pollutant dispersion model, dynamic trigger optimization model , dynamic display of simulation results and other key techniques in detail. Take the Qiantang River in Hangzhou section for example, this paper builds the water hydrodynamic model and the convection diffusion model, simulates the dispersion of assumed pollutants and then displays the fuctions of providing dynamic early warning services.The application shows that this system can provide accurate and convenient warning of the influence range and degree of water pollutants. It also provides decision support for relevant government departments, water companies and other enterprises to take emergency measures timely and effectively.
Eddy current testing is now a widely used Non Destructive Test (NDT) method for determining the size of cracks in metallic structures. The probability of detection (POD) is a key metric in assessing the effectiveness of nondestructive evaluation techniques. The POD analysis using common method is studied and modified. The eddy current sensor effective is discussed to support the proposed method. The new method is shown better result in improve the POD than the common one. The estimates of POD as a function of crack size will be valuable for future model-assisted POD study.
In this paper, a platform based on SaaS cloud computing framework is developed to provide professional online cloud simulation service for water quality assessment. The DLL, WINDOWS MFC programming methods are investigated and water pollution remote simulation can be performed supported by different water simulation softwares including MATLAB, MIKE and FLUENT. The C# language is used in our programming. The major steps of establishing a water quality simulation model using FLUENT and MATLAB are introduced.
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