Despite the incidence rates of pancreatic cancer being low worldwide, the mortality rates remain high. To date, there is no effective drug treatment for pancreatic cancer. Numerous signalling pathways and cytokines regulate the occurrence and development of pancreatic cancer. Ferroptosis is a non-traditional form of cell death resulting from iron-dependent lipid peroxide accumulation. Studies have demonstrated that ferroptosis is associated with a variety of different types of cancer, such as breast cancer, hepatocellular carcinoma and pancreatic cancer. The present study demonstrated that ferroptosis controls the growth and proliferation of pancreatic cancer, providing a new approach for the treatment of pancreatic cancer. Iron metabolism and reactive oxygen species metabolism are the key pathways involved in ferroptosis in pancreatic cancer. In addition, a number of regulators of ferroptosis, such as glutathione peroxidase 4 and the cystine/glutamate antiporter system Xc-, also play pivotal roles in the regulation of ferroptosis. In the present review, the regulatory mechanisms associated with ferroptosis in pancreatic cancer are summarized, alongside other associated forms of digestive system cancer. The treatment of ferroptosis-based diseases is also addressed.

Review question / Objective: We aim to investigate the clinical effect of postrewarming fever (PRF) after targeted temperature management (TTM) in cardiac arrest patients. Condition being studied: Post-rewarming fever (PRF), or rebound hyperthermia (RH), was observed in many patients who received argeted temperature management (TTM). However, previous studies about the influence of PRF on neurological outcome showed conflicting results. The aim of this INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols

Aim: To characterize and summarize the studies regarding the influence of post-rewarming fever on neurological outcome and mortality in cardiac arrest patients. Methods: Two investigators separately screened relevant articles in EMBASE, PubMed, and Cochrane Central databases. Randomized clinical trials (RCTs) and cohort studies that evaluated the influence of post-rewarming fever (PRF) and normothermia in cardiac arrest patients were included. The meta-analysis was performed using a random effects model or a fixed effects model to calculate the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs). The primary outcome was the unfavorable neurological outcome and the secondary outcome was the mortality. Results: The meta-analysis included 12 studies involving 2,991 patients. Results of quantitative analysis suggested that PRF (body temperature >37.5°C) did not affect the unfavorable neurological outcome of patients with cardiac arrest (OR, 0.82; 95% CI, 0.54-1.25; I2, 81%). Also, PRF (body temperature >37.8°C) was not related to higher mortality of patients with cardiac arrest (OR, 0.86; 95% CI, 0.55-1.34; I2, 74%). However, PRF with higher body temperature (>38.5℃) was associated with higher mortality (OR, 2.22; 95%CI, 1.40- 3.35; I2, 0%). Conclusions: This study suggests that PRF (body temperature >37.5°C) is not related to neurological outcome. And no significant association is found between PRF (body temperature >37.8°C) and mortality. However, PRF is associated with higher mortality when PRF was defined as >38.5℃.