ObjectiveNo definitive chemotherapeutic regimen has been established in patients with non-small-cell lung cancer (NSCLC) who failed second- or third-line treatment. The aim of this study was to evaluate apatinib, a VEGFR-2 inhibitor, in advanced NSCLC as salvage treatment.MethodsWe evaluated the efficacy and toxicity of apatinib in patients with previously treated advanced NSCLC from 2014 to 2015 in Zhejiang Cancer Hospital. Survival analysis was performed by the Kaplan–Meier method.ResultsForty-two patients were included in the present study. Four patients achieved partial response, and 22 achieved stable disease, representing a response rate of 9.5% and a disease control rate of 61.9%. Median progression-free survival and overall survival were 4.2 and 6.0 months, respectively. The toxicities associated with apatinib were generally acceptable with a total grade 3/4 toxicity of 50%.ConclusionApatinib appears to have some activity against advanced NSCLC when utilized as salvage treatment.

Spiro‐OMeTAD is one of the most used hole transport layers (HTLs) in high efficiency n‐i‐p perovskite solar cells (PSCs). However, due to the unsatisfactory conductivity of pristine Spiro‐OMeTAD, additives such as tert‐butylpyridine (tBP) and lithium bis (trifluoromethylsulfonyl)‐imide (LiTFSI) are required to improve its hole transportation. The hygroscopic nature of these additives inevitably deteriorates the device's stability. Here, it is shown that by adding fluorinated graphene (FG) into the Li‐TFSI and tBP doped Spiro‐OMeTAD, both efficiency and stability of the PSCs are significantly enhanced. Using the FG incorporated Spiro‐OMeTAD HTL, the power conversion efficiency (PCE) of the PSC reaches 21.92%, which is 11.8% higher than the original device. The FG not only improves the hole mobility of Spiro‐OMeTAD but also effectively reduces the amount of lithium ions in the perovskite layer and improves the hydrophobicity of the HTL. The FG incorporating cell shows better stability, maintaining 90% of initial efficiency over a 2400 h test in ambient conditions with 25% humidity. Finally, it is further demonstrated that the valence band of FG incorporated Spiro‐OMeTAD HTL has a positive effect on PSCs with a 2D interfacial layer, achieving an impressive PCE of 23.14% and a Voc of 1.226 V.

Incorporating Lewis base polymers into a perovskite layer has been demonstrated as one of the most effective routes to passivate trap states at the grain boundaries, whereas the inferior electrical conductivity of polymers than that of perovskite would inevitably hinder charge transport across the perovskite grains. Herein, we reported a strategy of utilizing highly conductive graphene/Lewis base polymer (PM6 or PM7) composites as additives in perovskite, which simultaneously passivates the defects and facilitates charge transport in the film. We further revealed in the work that halogen elements (Cl/F) in the polymer (PM6/PM7) can p-dope the graphene and endow it with higher hole-transport selectivity, which is of critical importance as ambipolar charge transport without selectivity would induce significant charge recombination in graphene. By this design, we achieved an outstanding efficiency of 21.21%, which is significantly higher than that of the pristine device without treatment. The device also exhibited impressive stability by retaining 90% of its initial power conversion efficiency after 480 h aging in ambient air with a ∼35% relative humidity at room temperature.