Background and Importance: Typhoid fever is an acute infection caused by Salmonella typhi, especially when it is waterborne or foodborne. Overripe pineapple causes typhoid fever because overripe pineapple is a desirable host for the survival of S. typhi. The importance of typhoid fever as a public health burden is reduced by early detection and appropriate antibiotic treatment. Case Presentation: A 26-year-old black African male health care worker was admitted to the clinic on 21 July 2022, with a significant chief complaint of headache, loss of appetite, and watery diarrhea. The admitted patient presented with a 2-day history of hyperthermia, headache, loss of appetite, and watery diarrhea, as well as back pain, joint weakness, and insomnia. The H antigen titer was positive, which was 1 : 189 greater than the normal range and showed the past history of S. typhi infection. The O antigen titer value detected was a false negative result because it was done before the 7-day onset of fever. On admission, ciprofloxacillin 500 mg was given orally twice a day for 7 days to treat typhoid by inhibiting the deoxyribonucleic acid replication of S. typhi by preventing S. typhi deoxyribonucleic acid topoisomerase and deoxyribonucleic acid gyrase. Clinical Discussion: Typhoid fever pathogenesis is based on pathogenic factors, infecting species, and host immunity. By using the agglutination biochemical test, the Widal test was able to identify the patient’s bloodstream as carrying the S. typhi bacteria that causes typhoid fever. Conclusion: Due to contaminated food or unsafe drinking water sources, typhoid fever is associated with travel to developing nations.

Background and importance: Acute pancreatitis is a pancreatic inflammatory condition that has the potential to cause serious morbidity. Acute pancreatitis is a relatively uncommon and potentially fatal pregnancy condition. Abdominal pain, pancreatic damage, or acute pancreatitis may all be related to the coronavirus disease 2019 (COVID-19) infection. Case presentation: On 12 August 2022, a 33-year-old black woman, gravida three, para two, a housewife, was taken to the obstetric care unit at 24 weeks of pregnancy with a 1-week history of lethargy, fever, and a dry cough. Reverse transcriptase-PCR testing on a sample of her nasopharyngeal swab revealed the presence of the severe acute respiratory syndrome coronavirus 2 virus. An abdominal computed tomography scan indicated an atrophic pancreas with broad fatty infiltration, little fluid and fat stranding around the pancreas, and reactive lymph nodes. She received 24-h-long insulin infusion therapy in addition to potassium chloride administered intravenously. She received crystalloid isotonic intravenous fluid to treat her severe pancreatitis and stop the progression of acute respiratory distress syndrome. Clinical discussion: Severe consequences of the severe acute respiratory syndrome coronavirus 2 infection are more likely to affect pregnant women who already have diabetes as concomitant conditions. Acute pancreatitis caused by COVID-19 is uncommon and can occur after a mild infection or even after the viral infection has cleared up. Lipasemia typically manifests following the peak of systemic inflammatory activity that triggers the release of pancreatic enzymes like lipase. Conclusion: Symptoms of the digestive system, including anorexia, nausea, vomiting, stomach pain, and diarrhea, can be brought on by the COVID-19 infection. She had diarrhea as a clinical symptom, showing that the COVID-19 infection was the root cause of her acute pancreatitis. She had also refrained from vomiting, demonstrating that her acute pancreatitis was not related to pregnancy.

Background and importance: Infection with coronavirus disease 2019 (COVID-19) worsens insulin resistance and causes diabetic ketoacidosis (DKA). Patients with COVID-19 infection who develop DKA run the risk of worse outcomes. In both diabetic and nondiabetic patients, the COVID-19 infection may hasten the development of ketoacidosis, which could have negative effects on the fetus. Case presentation: A 61-year-old retired Black African female was taken into the emergency room on 22 April 2022, with significant complaints of frequent midnight urination, shortness of breath, blurry vision, and tingling in her hands and feet. On a chest radiography, bilateral diffuse, patchy airspace opacities that might be due to multifocal pneumonia or viral pneumonia were seen. The severe acute respiratory syndrome infection was confirmed by real-time reverse transcription-PCR testing from nasopharyngeal swabs. She received intravenous fluids and an intravenous insulin infusion and monitored her blood electrolyte levels as part of her treatment. She received subcutaneous enoxaparin 80 mg every 12 h a day for prophylaxis of deep venous thrombosis due to her confirmed COVID-19. Clinical discussion: In a large number of patients, COVID-19 has the ability to trigger DKA, and type 2 diabetes mellitus amplifies the underlying COVID-19 infection. Diabetes mellitus and COVID-19 are noted to have a reciprocal relationship in this regard. Conclusions: By making the body resistant to insulin and raising blood sugar levels, a COVID-19 infection can cause DKA. It is probable that her severe acute respiratory syndrome coronavirus 2 infection has a detrimental effect on the pancreatic beta cells, which are responsible for her body producing insufficient levels of insulin.