Lidocaine and ropivacaine may inhibit neurogenic inflammation by biochemical pathways activated by SP, whereas bupivacaine seems to have no influence on this process.

PURPOSE:To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats. METHODS:Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting. RESULTS:No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups. CONCLUSION:The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats.

Purpose:To investigate the relevance of the term superficial musculoaponeurotic system (SMAS) and demonstrate that this term is important enough to be added to the MeSH database and listed in International Anatomical Nomenclature. Methods: Terms related to SMAS were selected from original articles retrieved from the ISI Web of Science and MEDLINE (PubMed) databases. Groups of terms were created to define a search strategy with high-sensitivity and restricted to scientific periodicals devoted to plastic surgery. This study included articles between January 1996 and May 2009, whose titles, abstracts, and keywords were searched for SMAS-related terms and all occurrences were recorded. Results: A total of 126 original articles were retrieved from the main periodicals related to plastic surgery in the referred databases. Of these articles, 51.6% had SMAS-related terms in the abstract only, and 25.4% had SMAS-related terms in both the title and abstract. The term 'superficial musculoaponeurotic system' was present as a keyword in 19.8% of the articles. The most frequent terms were 'SMAS' (71.4%) and superficial musculoaponeurotic system (62.7%). Conclusion: The term SMAS refers to a structure relevant enough to start a discussion about indexing it as a keyword and as an official term in Terminologia Anatomica: International Anatomical Terminology. Key words: Medical Subject Headings. Terminology. Surgery, Plastic. Abstracting and Indexing as Topic. Anatomy. RESUMOObjetivo: Investigar a relevância do termo sistema musculoaponeurótico superficial (SMAS) para propor a sua indicação para indexação como palavra-chave e inclusão na Terminologia Anatômica Internacional. Métodos: Termos relacionados ao SMAS foram recuperados de artigos originais identificados por mapeamento automático nas bases ISI Web Of Science e MEDLINE (PubMed). Os termos foram agrupados a fim de formar uma estratégia de busca de alta sensibilidade, limitada a periódicos exclusivos da especialidade de Cirurgia Plástica. Destes periódicos, foram selecionados artigos publicados de janeiro de 1996 a maio de 2009. Avaliou-se o título, resumo e as palavras-chaves, computando-se todas as ocorrências de termos relacionadas ao SMAS. Resultados: Recuperou-se um total de 126 artigos originais de periódicos relevantes, especializados em cirurgia plástica, e indexados nas bases mencionadas. Destes artigos, 51,6% apresentavam termos relacionados com SMAS somente no resumo, e 25,4% apresentavam termos relacionados com SMAS no título e resumo. O termo sistema musculoaponeurótico superficial estava presente como descritor em 19,8% dos artigos. As ocorrências mais freqüentes foram SMAS (71,4%) e sistema musculoaponeurótico superficial (62,7%). Conclusão: O termo SMAS, referente à estrutura em estudo, apresentou relevância suficiente para ser indexado como palavra-chave e listado na Terminologia Anatômica Internacional.