Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.

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RESUMOEste estudo indicou os produtos florestais não madeireiros (PFNM) associados a espécies arbóreas dos remanescentes de Floresta Ombrófila Densa estudados no Sul de Santa Catarina. As espécies analisadas foram hierarquizadas com base na análise de valor potencial de exploração sustentável (VPES) dos PFNM, integrando-se às seguintes informações obtidas a partir de revisão bibliográfica: densidade, parte usada, capacidade de regeneração natural e crescimento, conhecimento sobre biologia reprodutiva e dinâmica populacional, processamento requerido e nível de injúria ou toxicidade. Os resultados obtidos evidenciam ser possível a conservação e desenvolvimento regional, a partir de alternativas sustentáveis de uso dos recursos florestais. Das 79 espécies observadas, 38 atingiram VPES igual ou superior a 10, sendo consideradas de elevado potencial de exploração sustentável de PFNM. Palavras-chave: Floresta Ombrófila Densa; biodiversidade; VPES; recursos naturais. ABSTRACTThis study indicated the non-timber forest products (NTFPs) associated with tree species of the remnants of Tropical Rain Forest studied in southern Santa Catarina. The species examined were ranked according to their potential value for sustainable exploitation (PVSE) of NTFP, applying the following information obtained from literature review: density, parts used, capacity for natural regeneration and growth, knowledge about reproductive biology and population dynamic, required processing and level of injury or toxicity. The results show possible conservation and regional development, from alternative sustainable use of forest resources. Of the 79 species observed, 38 reached PVSE equal or higher than 10, being considered of high potential for sustainable exploitation of NTFP.

Resumo Fez-se uma análise por meio de indicadores bibliométricos, em artigos científicos publicados até o ano de 2013 nas