Background: Erlotinib is a Human Epidermal Growth Factor Receptor Type 1/tyrosine kinase (EGFR) inhibitor which is used for non-small-cell lung cancer treatment. Despite that erlotinib is considered to have a favorable safety profile, adverse events such as interstitial lung disease (ILD) were reported in pivotal studies. The authors report the first histologically confirmed case of fatal ILD associated with erlotinib therapy.

The internal temperature of Li-ion batteries for electric or hybrid vehicles is an important factor influencing their ageing. Generally not measured, it can be reconstructed from an external measurement and a model. This paper presents the simplified modelling of heat transfers in a battery module, leading to a Linear Parameter-Varying (LPV) model. Then, a polytopic observer is proposed to estimate the cell temperature and internal resistance, ensuring a tradeoff between the convergence speed and the noise of the estimated states. Experimental results show the good quality of the estimation and the diagnosis potential offered by internal resistance reconstruction.

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Data maps are easy to put in place and require very low calculation time. As a consequence they are often valued over fully physic-based models. This is particularly true when it is question of turbochargers. However, even if these maps are directly provided by the manufacturer, they usually do not cover the entire engine operating range and are poorly discretized. That's why before implementing them into any model they need to be interpolated and extrapolated.This paper introduces a new interpolation/extrapolation method based on the idea of integrating more physics into the widespread Jensen and Kristensen's method [6]. It essentially relies on the turbo machinery equation analysis performed by Martin during his PhD thesis [9, 10, 11] and the interpolation and extrapolation strategies that he proposed. In most cases the new strategies presented in this paper rely on improvements of the models he proposed. However the major issue here is to associate to each model a robust algorithm to obtain the fully extrapolated data maps from the raw manufacturer's data.The major outcomes of the study are: -new models for compression ratio and turbine flow rate extrapolations androbust and easy to implement algorithms for interpolation and extrapolation to low rotational speeds. These address single stage turbocharging configurations with fixed geometry turbines (in the case of variable geometry turbines, taking each position as a different fixed geometry turbine allow to use the same algorithms).