No abstract

Several carbocyclic nucleoside analogs possessing a 6‐substituted purine linked to a mesylated muco‐inositol were synthesized. The coupling of triethylamine‐activated 6‐chloropurine with 2,3‐anhydro‐l,5,6‐tri‐O‐(methanesulfonyl)‐epi‐inositol gave a 6‐chloro purinyl muco‐inositol amenable to further synthetic transformations in the heterocyclic moiety by substitution of the chlorine atom by nitrogen nucleophiles such as methylamino, diethylamino, benzylamino, hydrazino, morpholino, hydroxylamino, piperidino, and glycyl groups.

Ausgehend von dem Tetramesylat (I) werden, wie im Formelschema angegeben, die Epoxide (II), (IV) und (V) sowie das Diepoxid (VI) in Form der Racemate synthetisiert.

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