Metal-organic framework (MOF) nanosheets have attracted significant interests for sensing, electrochemical, and catalytic applications. Most significantly, 2D MOF with highly accessible sites on the surface is expected to be applicable in data storage. Here, the memory device is first demonstrated by employing M-TCPP (TCPP: tetrakis(4-carboxyphenyl) porphyrin, M: metal) as resistive switching (RS) layer. The as-fabricated resistive random access memory (RRAM) devices exhibit a typical electroforming free bipolar switching characteristic with on/off ratio of 10 3 , superior retention, and reliability performance. Furthermore, the time-dependent RS behaviors under constant voltage stress of 2D M-TCPP-based RRAMs are systematically investigated. The properties of the percolated conducting paths are revealed by the Weibull distribution by collecting the measured turn-on time. The multilevel information storage state can be gotten by setting a series of compliance current. The charge trapping assisted hopping is proposed as operation principle of the MOF-based RRAMs which is further confirmed by atomic force microscopy at electrical modes. The research is highly relevant for practical operation of 2D MOF nanosheet-based RRAM, since the time widths, magnitudes of pulses, and multilevel-data storage can be potentially set.

Combination delivery systems composed of injectable hydrogels and drug-incorporated micelles or nanoparticles with tunable and convenient properties for clinical operation and storage are urgently demanded in regional cancer chemotherapy to prolong and control drug release, enhance antitumor efficiency and decrease side effects. Previously, we developed a novel thermosensitive amphiphilic triblock copolymer, poly (3-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)poly (3-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT), and fabricated a reconstituted "two into one" combination system of thermosensitive injectable hydrogel PTX/PECT Gel , assembled from paclitaxel (PTX)-loaded PECT nanoparticles (NPs). PTX/PECT Gel could be stored as freeze-dried powders of paclitaxel-loaded PECT NPs, which could be reconstituted into aqueous fluid dispersions at ambient temperature just by mixing with water after gentle stirring for several minutes, and form a hydrogel at the injected site in vivo. Herein, the drug release, in vivo morphology, antitumor efficiency and pharmacokinetic properties of PTX/PECT Gel were evaluated. The PTX/PECT Gel combination system could continuously release PTX in a near linear manner over 42 days in vitro, and simultaneously, PTX/PECT NPs containing 75% of the total released PTX could dissociate from the PTX/PECT Gel . PTX/PECT Gel exhibited remarkable in vitro anti-proliferative activities against Ehrlich ascites carcinoma (EAC) cancer cells. The peritumorally or intratumorally injected PECT gel could cover the entire surface or fill up the interior space of the tumor, respectively. A single peritumoral injection of the PTX/PECT Gel formulation at a low dosage of 10 mg kg À1 could completely inhibit the growth of an EAC tumor inoculated in Balb/c mice after the first week, and the inhibition could be sustained for more than 21 days. The plasma pharmacokinetic study demonstrated that PTX/PECT Gel could greatly decrease the systemic exposure of PTX, as confirmed by the rather low plasma concentration. On the other hand, the PTX concentration in normal tissues with the intratumoral injection of PTX/PECT Gel was approximately 2 mg g À1 , which was 3-10 times lower than that with the intraperitoneal or intratumoral injection of TaxolÒ, implying fewer off-target side effects. These data confirmed that the PTX/PECT Gel combination local delivery system could vastly prolong the in vitro and in vivo paclitaxel release, enhance the local tumor inhibition effect and lower the systemic exposure and tissue distribution of paclitaxel. Hence, the "two into one" PTX/PECT Gel system holds underlying value for regional cancer chemotherapy.

Purpose-RFID has fundamental influences on today's retailing and supply chain management. This article seeks to formulate the opportunities and challenges of RFID adoption in China. Design/methodology/approach-Field interview and panel discussion were used to explore the opportunities and challenges of RFID adoption in China. An example of successful RFID deployment in China is presented. Findings-Although Chinese companies are exposed to several challenges in the adoption of RFID, there are numerous opportunities for RFID deployment. Challenges include China's standards, costs, business environment, business models, and untested market. The opportunities include China's huge market size, advances of several industries, a rapid increase in logistics demand, and China's role as a world-class manufacturing center. Originality/value-This article represents a pioneer study of RFID adoption in China. Opportunities and challenges of RFID adoption in China were identified, which provide valuable guidance for RFID adoption for Chinese companies and foreign companies operating in China.

Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and Hai zao (Sargassum pallidum), and has traditionally been used for softening hard lumps and resolving hard tissue masses. However, the active compounds and mechanisms of action of RJSJ remain unknown. The present study demonstrated the antitumor activity of RJSJ against Ehrlich ascites carcinoma in Swiss albino mice and breast cancer xenografts in nude mice. Notably, RJSJ does not induce body weight loss, immune function toxicity or myelosuppression in mice, indicating that it is safe and well tolerated. In addition, RJSJ shows potent cytotoxicity against breast cancer cells in vitro by the suppression of the anti-apoptotic proteins B-cell lymphoma 2 and survivin, leading to the activation of caspase-3/7 and caspase-9, and the apoptotic cascade. These findings provide a clear rationale to explore the therapeutic strategy of using RJSJ alone or in combination with chemotherapeutic agents for breast cancer patients and the characterization of its active principles.

In article number https://doi.org/10.1002/adfm.201806637, Ye Zhou, Su‐Ting Han, and co‐workers demonstrate a 2D metal‐organic framework nanosheet based memory device with a typical bipolar switching behaviour, superior retention, and high reliability. The devices show excellent multilevel information storage performance, and the percolated conducting paths model has been verified by the Weibull distribution.