Objective: The aim of this study is to determine the histopathological examination of medicolegal autopsy cases and its correlation with causes of death. Study Design: Retrospective/observational Place and Duration: This study was conducted at department of Pathology, Khairpur Medical College Khairpur Mir's for duration of eight months from 15thMay, 2020 to 15thJanuary, 2021. Methods: Hundred cases of both genders were presented in this study. Cases were aged between 15-75 years. Cases detailed demographics age, sex and body mass index were calculated after taking informed written consent from authorities. Autopsy laboratory was used to take medicolegal autopsies of enrolled cases. 10% formalin solution was used for histopathological examination of all the specimens. In the course of the post-mortem investigation we examined the histopathology results for five major organs, such as the brain, heart, lung, liver and kidneys and compared them with gross anatomical results. Complete data was analyzed by SPSS 24.0 version. Results: 62 (62%) cases were males and 38 (38%) patients were females. Mean age of the participants were 30.52±13.17 years with mean BMI 24.52±16.21kg/m2. Most of the participants 40 (40%) were aged between 25-35 years of age followed by 27 (27%) were aged between 36-45 years. Most of the participants 70 (70%) were from urban area and the rest were 30 (30%) from rural area. Instant death was the most common cause found in 35 (35%) cases, followed by traffic accidents 24 (24%) cases. Most frequent effected organs were lung 29%, heart 26%, liver 21% and brain 18%. In lungs pneumonia was the most common effected pathology among 20 (68.97%) and in heart atherosclerosis was the most common effected pathology among 21 (80.77%). Conclusion: In medicolegal autopsy cases, histopathological analysis may be regarded as a useful method. The most common organ in these cases were the heart, liver and lungs. In certain cases, the histopathological exam of these bodies has been useful in identifying the cause of death. Often pathological results included pneumonia, atherosclerosis and congestion. Keywords: Histopathology, Medicolegal, Cause of death, Autopsy

Objective: To determine the adverse effects of formula milk in infants presented to our institution. Study Design: Retrospective/observational Place and Duration:The study was conducted at Paediatric Department of Liaquat University Medical Hospital Jamshoro and Civil Hospital Khairpur Mir's. Methodology: Total 85 formula-fed infants of both genders with ages upto 2 years were included in this study. Detailed demographics including age, sex, weight, residence and socio-economic status were recorded after taking informed written consent from guardians/parents. Adverse effects such as iron deficiency, low weight, gastroenteritis, type I diabetes mellitus and autoimmune disease were examined. Data was analyzed by SPSS 24.0. Results: There were 45 (52.94%) females whiles 40 (47.06%) were males. Mean age was 1.86±1.02 years. 52 (61.18%) patients had urban residence and majority 50 (58.82%) had high socio-economic status. Iron deficiency was found in 38 (44.71%) infants, 32 (37.65%) infants had abnormal low weight, 24 (28.24%) had gastroenteritis/diarrhea, 18 (21.18%) infants had type I diabetes and 14 (16.47%) infants had autoimmune disease. Conclusion: It is concluded that formula milk was associated with many of adverse effects, the most common was iron deficiency and low weight. Mothers should be aware of these adverse effects of formula fed. Keywords: Formula Milk, Infants, Iron Deficiency, Low Weight, Infection, Type I Diabetes