The infectious disease from  corona virus, or COVID-19, has quickly spread world-wide since 2019. Therapies for managing COVID-19 have yet to be confirmed as medication for the severe sickness that the disease may cause. This study uses PRISMA guidelines as a method for conducting a systematic literature review. We selected relevant studies published from January 2020 to March 2020 by searching Pubmed, Science Direct and Google Scholar. The research focuses on the treatment of and therapies for COVID-19 only to the patients in the hospital. The inclution 8 articles  were screened by using a PRISMA flow after reading 28 abstract  and 28 from whole articles. Sixty-seven articles were collected from several online journal databases, and various therapies were found that are effective in the treatment and management of COVID-19. Clinical improvements and Recovery rate have been achieved in a short time compared to standard care only. The findings of the study show that several therapies are effective in managing the severe illness that can be caused by COVID-19. Nevertheless, research into effective therapies for COVID-19 must be continued to find the best therapy and treatment.