Current prognostic signatures need to be improved in identifying high‐risk patients of gastric cancer (GC). Thus, we aimed to develop a reliable prognostic signature that could assess the prognosis risk in GC patients. Two microarray datasets of GSE662254 (n = 300, training set) and GSE15459 (n = 192, test set) were included into analysis. Prognostic genes were screened to construct prognosis‐related gene pairs (PRGPs). Then, a penalized Cox proportional hazards regression model identified seven PRGPs, which constructed a prognostic signature and divided patients into high‐ and low‐risk groups according to the signature score. High‐risk patients showed a poorer prognosis than low‐risk patients in both the training set (hazard ratios [HR]: 6.086, 95% confidence interval [CI]: 4.341–8.533) and test set (1.773 [1.107–2.840]). The PRGPs signature also achieved a higher predictive accuracy (concordance index [C‐index]: 0.872, 95% CI: 0.846–0.897) than two existing molecular signatures (0.706 [0.667–0.744] for a 11‐gene signature and 0.684 [0.642–0.726] for a 24‐lncRNA signature) and TNM stage (0.764 [0.715–0.814]). In conclusion, our study identified a novel gene pairs signature in the prognosis of GC.

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Abstract. As a key component of a hydraulic fineblanking press, a high speed hydraulic system is used to achieve the rapid movement of the slider in the noncutting stage, which is important for improving the processing efficiency. It is important to study the various properties of a high speed hydraulic system as the rapid movement affects the precision of the machine as well as the quality of the stamping parts. In this paper, a high speed hydraulic system model was established, and the static and dynamic characteristics of the key components in the system were simulated and analyzed. The system control logic was designed according to the blanking process, and the changes in the speed, displacement, pressure and flow of the high speed cylinder in the blanking process were analyzed. A strategy using PID feedback control of the system was proposed to improve the blanking precision and provide a reliable basis for the control system design.