Angiograms demonstrated a reduced disc flow index and vessel density in glaucoma, and this reduction was closely related to GCC thickness. This indicated that measurement of disc perfusion by angio-OCT might be important for the monitoring of glaucoma.

We have used anterior segment swept source optical coherence tomography to measure Schlemm's canal (SC) morphometric values in the living human eye. Fifty healthy volunteers with 100 normal eyes were measured in the nasal and temporal side. Comparison with the published SC morphometric values of histologic sections proves the reliability of our results. The statistical results show that there are no significant differences between nasal and temporal SC with respect to their diameter, perimeter, and area in our study (diameter: t=0.122, p=0.903; perimeter: t=-0.003, p=0.998; area: t=-1.169, p=0.244); further, no significant differences in SC morphometric values are found between oculus sinister and oculus dexter (diameter: t=0.943, p=0.35; perimeter: t=1.346, p=0.18; area: t=1.501, p=0.135).

Near-infrared (NIR)-light-triggered diagnostic and therapeutic systems normally are the integration of several components, whose complex structures and low reproducibility restrict their further applications. Herein, we proposed a single component of defect graphitic phase carbon nitride quantum dots (g-C 3 N 4 QDs) as a dual-functional nanoplatform, which could synchronously achieve two-photon imaging (TPI) and two-photon excited photodynamic therapy (TPE-PDT) under an 800 nm NIR laser. In order to regulate the competitive capability between TPI and PDT, three kinds of engineered g-C 3 N 4 QDs (CN, CN-DPT, and CN-THDT QDs) with different two-photon catalytic capabilities to generate reactive oxygen species (ROS) were prepared through copolymerization melamine with selected monomers. In the evaluation of in vitro cytotoxicity, three g-C 3 N 4 QDs possessed very good biocompatibilities, which could be delivered to tumor cells for imaging and therapy. Under an 800 nm NIR light, CN-DPT QDs exhibited a bright TPI effect and produced an efficient ROS to achieve TPE-PDT, thus suggesting that the single component of CN-DPT QDs could perform as an appropriate dual-functional TPI and TPE-PDT probe triggered by an 800 nm NIR light. The engineered g-C 3 N 4 QDs with a high stability and excellent biocompatibility have contributed to the method of TPI and TPE-PDT, which may lead to g-C 3 N 4 -based nanomaterials as novel imaging and therapeutic agents in cancer treatment. KEYWORDS: graphitic phase carbon nitride quantum dots (g-C 3 N 4 QDs), defects, near-infrared (NIR) light, two-photon imaging (TPI), two-photon excited photodynamic therapy (TPE-PDT)