No abstract

Bone metastasis of patients suffering from later-stage cancers is often observed. Half of the cancer patients will have bone metastasis. It causes pain of bone, pathological fracture, osteomyelitic weakening, difficulty in walking and nerves compression symptoms, sometimes, it is the cause of hypercalcemia.The effect of treating the pain caused by bone metastasis is not satisfactory. The only means is simply to give (analgetic) pain reliever which used in big dose may cause side-effect such as nausea, vomiting, constipation and so on, and its pain-relieving effect is not always satisfactory. In this study, 106 cases of late-staged cancers were selected to be treated with 89 Sr therapy and 89 Sr combined with regional radiotherapy, to investigate the effects of two treatments. Materials and methods Clinical materialsThe 106 cancers cases with multiple bone metastasis proven by CT, MRI and/or ECT were selected. Their original tumors were proved by pathological examinations. They were admitted in our Hospital or treated in our

SummaryElectroencephalogram‐microstate analysis was conducted using low‐resolution electromagnetic tomography (LORETA)‐KEY to evaluate dynamic brain network changes in patients with acute large artery atherosclerotic cerebral infarction (LAACI) during the rest and sleep stages. This study included 35 age‐ and sex‐matched healthy controls and 34 patients with acute LAACI. Each participant performed a 3‐h, 19‐channel video electroencephalogram test. Subsequently, 20 epochs of 2‐s sleep spindles during stage N2 sleep and five epochs of 10‐s electroencephalogram data in the resting state for each participant were obtained. In both the resting state and sleep spindles, patients with LAACI displayed altered neural oscillations. The parameters of microstate A (coverage, occurrence, and duration) increased during the resting state in the patients with LAACI compared with healthy controls. The coverage and occurrence of microstate B and D were reduced in the LAACI group compared with the healthy controls (p < 0.05). Moreover, during sleep spindles, the duration of microstate A and the transition probability from microstate A and B to C decreased, but the coverage of microstate B and the transition rate from microstate B to D increased (p < 0.05) in the LAACI group compared with the healthy controls. These results enable better understanding of how neural oscillations are modified in patients with LAACI during the resting state and sleep spindles. Following LAACI, the dynamic brain network undergoes changes during sleep spindles and the resting state. Continued long‐term investigations are required to determine how well these changes in brain dynamics reflect the clinical characteristics of patients with LAACI.