Nine new piperidinothienopyrimidinone derivatives were synthesized from the reaction of carbodiimide intermediate with primary, secondary amines and alcohols catalyzed by sodium alkoxide. The structures of the compound were confirmed by elemental analysis, 1 H NMR, MS and single crystal X-ray determination. The fungicidal activities of all the compounds were studied and some compounds exhibited good bacteriostasis activity. Among them, compound 7b exhibited fungicidal activity against Botrytis cinereapers, Rhizoctonia solani, and Gibberella zeae with inhibitive rates of 76.19%, 68.83% and 56.52%, respectively.

3-Isothiocyanato oxindoles have been widely employed as a class of highly reactive and novel reagents in the enantioselective synthesis of diverse spirooxindoles. This review summarizes the recent advances of 3-isothiocyanato oxindoles mediated some types of cascade process in the past six years, including properties of reaction, activation models and synthetic applications. Furthermore, the prospects of this concept are also discussed.

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