Hepatocellular carcinoma (HCC) is known to be the most common primary tumor of the liver and is also the fifth most common cancer in the world. Chronic hepatitis B and C along with type 2 diabetes mellitus and alcoholic liver disease are quite well-known risk factors for HCC, and it is uncommon in the noncirrhotic liver. HCC favors spreading as multifocal intrahepatic lesions and potential vascular invasion, and extrahepatic spread is uncommon. Skeletal metastasis from HCC occurs infrequently compared to other cancers and is common in the axial skeleton. Metastatic involvement of the appendicular skeleton is a rare entity, and the initial presentation of HCC as metastatic involvement of the appendicular skeleton is even rarer. We report a case of HCC with incidentally detected cirrhosis and chronic hepatitis B infection presenting with pain in the left shoulder.

Neurocysticercosis (NCC) is described as the central nervous system involvement by a parasitic infection caused by a nematode, Taenia solium. By far, NCC is the most common parasitic infection of central nervous system in the world. In the developing countries like India, NCC is a leading cause of epilepsy in all age groups. Here, we present a case of a 36-year-old male who was a known case of multiple NCC involving the brain having cognitive dysfunction and presented with difficulty in walking and sudden onset weakness of right lower limb. On contrast enhanced MRI of spine, an intramedullary lesion was seen at D7- D8 level, which was confirmed on histopathological examination of the excised tissue as NCC. During clinical follow-up, the patient has shown significant neurological improvement.

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Superficial CD34 positive fibroblastic tumour (SCD34FT) is a distinct mesenchymal tumour of superficial soft tissues which has an intermediate malignant potential and is a recently introduced entity in the WHO classification. We present a case report of a 32-year-old male patient with SCD34FT. The tumour was located on right forearm and was essentially superficial in location. Wide local excision of the tumour was done. On histopathological examination, the tumour was composed of highly pleomorphic spindled as well as epithelioid cells with granular eosinophilic cytoplasm and numerous bizarre lobulated nuclear forms with few showing intranuclear inclusions. However, the mitotic count was very low. On immunohistochemistry (IHC), tumour cells were diffusely positive for vimentin and CD34 (characteristic of SCD34FT). During clinical follow-up, the patient is asymptomatic since the time of his surgery one year back. SCD34FT is a mesenchymal tumour of borderline malignant potential which is restricted to the superficial location.

Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by one of several dematiaceous (naturally pigmented) fungi. Predominantly, an infection of the humid tropical and subtropical regions, chromoblastomycosis does occur in India, and its diagnosis is usually delayed due to the low level of clinical suspicion. Here, we present the case of a 65-year-old male who presented with gradually progressive raised lesions over the right thigh of 8 years' duration with a history of sustaining injury through horse tail. Dermatological examination revealed a well-defined, erythematous, verrucous plaque on the lower third of the right thigh and knee with ill-defined advancing margins. Histopathological examination of skin biopsy and potassium hydroxide preparation of material scraped from the surface of lesions showed characteristic “sclerotic bodies” of chromoblastomycosis, and the patient was started on anti-fungal drugs to which he responded very well with regression of most of his lesion.