It is widely acknowledged that rotary positive displacement machines exhibit highly unsteady flow fields that affect their performance. The presence of the operational clearances impacts this unsteady flow field and further affects the performance. However, the exact nature of these unsteady flow mechanisms remains largely unknown that necessitates both detailed experimental investigations and computational modelling. Thus, the present study employs both optical visualization and unsteady Reynolds-Averaged Navier Stokes (URANS) computational modelling methods while focussing on investigating the transient flow field inside a Roots blower, a general type of the rotary positive displacement machine. Straight lobes in a Roots blower provide convenient optical access to experimentally analyse internal flow and compare it with the predictions obtained by standard computational models. In the first part of this paper, this study covers the lowspeed experimental investigations using i) High-Speed Camera (HC), ii) the continuous High-Speed Particle Image Velocimetry (CPIV) and, iii) the instantaneous PIV (IPIV) obtained with a double pulse laser and a double shutter camera. Relative merits from these techniques are discussed with respect to the Roots blower unsteady flow mechanisms. In addition, computational analyses are performed using a combination of in-house and commercial modelling methods and the results are compared against the experiments. The results confirm the existence of highly three-dimensional and unsteady flow field where certain distinct flow mechanisms originating from the operational clearances impact the performance of the Roots blower. The study also highlights challenges of the experimental and computational methods used for evaluation of positive displacement machines that impact the accuracy of results.

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Abstract. The objective of the study was to investigate in vitro transdermal delivery of venlafaxine hydrochloride across the pigskin by passive diffusion and iontophoresis. For passive diffusion, experiments were carried out in Franz diffusion cell whereas for iontophoretic permeation, the diffusion cell was modified to contain both the donor and return electrode on the same side of skin. Anodal iontophoresis was carried out using a current density of 0.5 mA/cm 2 . Donor concentrations used were 585.5 mg/ml (saturated solution) and 100 mg/ml. Experiments initially performed to determine the transport efficiency of venlafaxine ions showed promising results. Iontophoresis increased the permeation rate at both concentration levels over their passive counterparts (P<0.01), but surprisingly higher steadystate flux was obtained from lower donor drug load (P<0.01). The favorable pH of the unsaturated solutions is suggested to be the cause for this effect. Mild synergistic effect was observed when iontophoresis was carried out incorporating peppermint oil in the donor but the same was not found in passive diffusion. Highest steady-state flux obtained in the experiment was 3.279 μmol/cm 2 /h when peppermint oil (0.1%) was included in the donor. As the maintenance requirement of venlafaxine hydrochloride is approximately 9.956 μmol/h, the results suggested that the drug is a promising candidate for iontophoretic delivery.

Computational fluid dynamics (CFD) can help in understanding the nature of leakage flow phenomena inside the rotary positive displacement machines (PDMs). However, due to the lack of experimental results, the analysis of leakage flows in rotary PDMs by CFD has not yet been fully validated. Particle image velocimetry (PIV) tests with a microscopic lens and phase-lock were conducted to obtain the velocity field around the tip gap in an optical Roots blower. The three-dimensional unsteady CFD model of the Roots blower with the dynamic grids generated by Screw Compressor Rotor Grid Generation (SCORG) was established to predict the gap flow under the same operating conditions. The images obtained by the PIV tests were analyzed and some factors which compromise the quality of test results in the gap flow were identified, such as reflections and transparency of the window. The flow fields obtained by CFD have the same flow pattern and velocity magnitude as the experimental results in the majority of observed regions but overestimate the leakage flow velocity. The CFD results show a vortex induced by the leakage flow in the downstream region of the gap. The flow losses in the tip gap mainly happen at the entrance upstream of the gap. Finally, some suggestions for future work are discussed.

The present study aims to investigate the interaction between a last-stage steam turbine blade row and diffuser. This work is carried out using computational fluid dynamics (CFD) simulations of a generic last-stage low-pressure (LP) turbine and axial–radial exhaust diffuser attached to it. In order to determine the validity of the computational method, the CFD predictions are first compared with data obtained from an experimental test facility. A computational study is then performed for different design configurations of the diffuser and rotor casing shapes. The study focuses on typical flow features such as effects of rotor tip leakage flows and subsequent changes in the rotor–diffuser interactions. The results suggest that the rotor casing shape influences the rotor work extraction capability and yields significant improvements in the diffuser static pressure recovery.