Purpose: To evaluate whether Accelerated CXL for 10 minutes is as effective as standard CXL for 30 minutes for the treatment of progressive keratoconus. Patients and Methods: Eighty-two eyes of 62 patients with keratometry examinations performed before and 6 months after surgery were studied. A total of 39 eyes underwent standard CXL with UVA irradiation of 3 mW/cm 2 for 30 minutes and 32 eyes underwent Accelerated CXL UVA irradiation of 9 mW/cm 2 for 10 minutes. The eyes of all patients had corneal thicknesses of at least 450 microns (400 microns after epithelium removal). Results: The means of the keratometry measurements in the preoperative period for the eyes subjected to standard CXL were 46.27 dioptres (D) on the flat axis (K1) and 48.93 D on the steep axis (K2). Postoperatively, K1 was 46.21 D and K2 was 48.97 D, a difference without statistical significance (p = 0.47 and p = 0.48, respectively). In the Accelerated CXL protocol, the preoperative measurements were 44.55 D and 46.19 D for K1 and K2, respectively. In the postoperative period, K1 was 43.37 D, and K2 was 46.64 D (p = 0.38 and p = 0.27, respectively). In the standard group, the mean maximum keratometry (Kmax) preoperatively was 55.87 D, with no statistical significance (p = 0.29). In the preoperative period, the Kmax of the Accelerated group was 51.15 D, with no statistical significance (p = 0.32). Conclusion: Based on the keratometry results, the accelerated protocol was as effective as the standard protocol for keratoconus stabilization.
A infecção por Helicobacter Pylori (HP) afeta bilhões de pessoas ao redor do mundo, sendo essa bactéria considerada o agente infeccioso mais prevalente nos seres humanos. Nos últimos anos, a literatura tem evidenciado uma possível associação entre essa infecção e o desenvolvimento de doença arterial coronariana (DAC), uma vez que ambas condições são consideradas doenças crônicas, compartilhando entre si de eventos fisiopatológicos semelhantes. O presente estudo objetiva avaliar a associação entre a infecção por HP e o risco de desenvolvimento de DAC. Para essa Revisão de Escopo, realizada através das plataformas PubMed e Cochrane Library entre 2022 e 2012, os descritores eleitos foram ‘’Helicobacter Pylori’’, ‘’Coronary Disease’’ e ‘’Heart’’, associados ao operador exclusivamente ao booleano ‘’AND’’. Os critérios de inclusão consistiram 1) ensaios clínicos, testes controlados e aleatórios, revisões e meta análises, 2) trabalhos acerca da associação entre DAC e HP, 3) estudos que avaliaram a extensão dos danos cardiovasculares em decorrência da infecção por HP e 4) artigos escritos em língua portuguesa, japonesa, inglesa ou em espanhol. Os critérios de exclusão incluíram inadequações ao tema, relatos de casos e estudos com animais, além de textos fora do limite temporal. As evidências encontradas sugeriram que os principais efeitos adversos cardiovasculares relacionados à infecção por HP estavam associados à DAC, a aterosclerose, a hipertensão arterial sistêmica e ao infarto agudo do miocárdio. Métodos de rastreio, avaliações intervencionistas e indicações para a utilização de marcadores laboratoriais, assim como mais análises clínicas acerca dessa interação ainda permanecem como tópicos a serem melhor elucidados.
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