ABSTRACT Chromoblastomycosis (CMB) is a polymorphic fungal disease that usually affects the lower limbs and manifests as verrucous nodules or plaques that may ulcerate. American Tegumentary Leishmaniasis (ATL) is an infectious parasitic disease caused by digenetic protozoa of the genus Leishmania sp. which affects the skin and/or mucous membranes of man and various species of wild and domestic animals. Both are part of the World Health Organization (WHO) neglected tropical diseases portfolio, mostly affecting economically vulnerable populations without adequate sanitation and in close contact with infectious vectors. We present the report of a 59-year-old male patient, referred to the Hospital Geral Público de Palmas (HGPP) in December 2017, carrying a positive result from a direct parasitological detection test for Leishmania sp., in addition to multiple previously biopsied lesions caused by CMB. It was observed that the patient had an important improvement of the CMB lesions with the use of amphotericin B in combination with itraconazole, thus demonstrating the role that the former can play in the therapy of this fungal disease.   Keywords: Chromoblastomycosis; American Tegumentary leishmaniasis; Amphotericin B. RESUMO A cromoblastomicose (CBM) é uma doença fúngica polimórfica, que acomete normalmente os membros inferiores e que se manifesta como nódulos ou placas verrucosas que podem ulcerar. A leishmaniose tegumentar (LT) é uma doença infectoparasitária causada por protozoários digenéticos do gênero Leishmania sp. que acomete a pele e/ou mucosas do homem e de várias espécies de animais silvestres e domésticos. Ambas fazem parte do portfólio de doenças negligenciadas da Organização Mundial da Saúde (OMS), afetando em sua maioria pessoas economicamente vulneráveis, sem saneamento adequado e em contato próximo com vetores infecciosos. Apresentamos neste trabalho o relato de um paciente, masculino, 59 anos, encaminhado ao Hospital Geral Público de Palmas (HGPP) em dezembro de 2017, portando exame parasitológico direto positivo para Leishmania sp., além de múltiplas lesões causadas por CBM previamente biopsiadas. Foi observado que o paciente teve importante melhora das lesões de CBM com uso da anfotericina B em associação ao itraconazol, demonstrando o papel que essa droga pode exercer na terapêutica desta doença fúngica. Palavras-chave: Cromoblastomicose; Leishmaniose Tegumentar; Anfotericina B.

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Cardiac tumors are uncommon conditions in medical practice, and among them, the most prevalent is the myxoma. Despite their benign nature, myxomas may have behavior suggestive of malignancy and serious consequences. They may have cardiovascular repercussions associated with nonspecific systemic manifestations, which often hinder their diagnosis, benefiting their evolution and increasing the risks of serious complications, including embolic alterations and death. We present, in this work, the case report of a child admitted to the Hospital Infantil Público de Palmas (HIPP), with clinical history of abdominal distension, adynamia, hyporexia and intermittent fever, initially diagnosed with right atrial myxoma. The patient had different epidemiological characteristics than those described in the literature for cardiac myxomas. This, combined with the fact that cardiac myxomas have a low incidence and commonly present in non-specific cardiovascular and constitutional manifestations, made it difficult to diagnose and delay surgical treatment. Attention to the possibility of this disease and the echocardiogram in the evaluations may facilitate the early diagnosis of this benign cardiac neoplasia.