Abstract:© Versita Sp. z o.o. ) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin.

Abstract.A new complex of palladium was isolated with 2-furoic hydrazide (FH) and characterized by spectroscopic methods. The results show that the ligand is coordinated to palladium by the basic nitrogen of NH 2 group and has a general structure of type cis-[Pd(FH) 2 Cl 2 ]. The structure of palladium(II) complex was optimized and theoretical data show good agreement with the experimental results. The cytotoxic activity was evaluated in a chronic myelogenous leukemia cell line, which revealed that the compound is less active than cisplatin or carboplatin. At 300 g mL −1 , the complex presented antimicrobial activity more efficient than ampicillin, chloranfenicol and kanamicyn. (doi: 10.5562/cca2151)

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