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Acute Myocardial Infarction Resulting from Takotsubo Cardiomyopathy in Patient on Antihistaminics Associated to Pseudoephedrin This is the report on a 77-year-old female patient on antihistaminic associated to pseudoephedrin to treat an allergy condition in upper airways. The patient was admitted to the Emergency Unit with acute myocardial infarction and ST segment elevation in the antero-lateral wall. Cardiac catheterism showed tortuous coronaries, no obstructive lesions, and baseline hypercontractility associated to antero-apical akinesia on left ventriculography. As a result of repeated pericardial strokes, the patient was submitted to pleuro-pericardial drainage. Rheumatological causes were ruled out. The patient was discharged after 30 days in good clinical conditions.

To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes. Methods: A prospective histomorphometric study was performed on 29 hearts of Wistar fourmonth old rats. Animals were divided into three groups: Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis. Results: Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG. Conclusion: Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.