Endogenous virus elements (EVEs) are viral-derived sequences integrated into their host genomes. EVEs of the Jingchuvirales order were detected in a wide range of insect genomes covering several distantly related families. Moreover, Jingchuvirales -derived glycoproteins were recently associated by our group with the origin of a putative new retrovirus based on a glycoprotein captured by a mosquito retrotransposon. But, except for mosquitoes, there is a lack of a more detailed understanding of the endogenization mechanism, timing, and frequency per Jingchuvirales viral lineages. Here we screened Jingchuvirales glycoprotein-derived EVEs (Jg-EVEs) in eukaryotic genomes. We found six distinct endogenization events of Jg-EVEs, that belong to two out of five known Jingchuvirales families ( Chuviridae and Natareviridae ). For seven arthropod families bearing Jg-EVEs there is no register of bona fide circulating chuvirus infection. Hence, our results show that Jingchuvirales viruses infected or still infect these host families. Although we found abundant evidence of LTR-Gypsy retrotransposons fragments associated with the glycoprotein in Hymenoptera and other insect orders, our results show that the widespread distribution of Jingchuvirales glycoproteins in extant Arhtropods is a result of multiple ancient endogenization events and that these virus fossils are being vertically inherited in Arthropods genomes for millions of years.

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The respiratory system has a vital function in our body and several disorders can cause Respiratory Insufficiency (RI). This disease, in turn, has an acute or chronic form, as well as being classified as hypoxemic, hypercapnic and mixed. In addition, there are three groups that cover the causes of RI, which are: hypoventilation, impairment of diffusion and disturbances in the relationship between perfusion ventilation. With regard to clinical manifestations, the respiratory system is affected by this condition, from which the diagnosis of RI is made by blood gas analysis that allows to differentiate it. In these cases, the patient is monitored by oximeters and capnographs, the treatment being carried out by oxygen therapy and the use of invasive and non-invasive mechanical ventilation.