We present the case of an OLP with rectal activity in a patient with HIV, treated with radiotherapy during the SARS-CoV-2 contingency. Presentation of the caseA 38-year-old male, homosexual, with a condition of more than 12 months of evolution, characterized by persistent proctalgia and rectal bleeding associated with a palpable lesion in the anal region, profuse night sweats, and weight loss of 8 kg in 2 months. He was approached by a proctologist who diagnosed a perianal abscess, drained the abscess, and resected the perianal lesion; however, after the surgical procedure, she continued with symptoms and the appearance of new tumor growth in the gluteal and perianal region. He went again to a proctologist who performed a rectosigmoidoscopy in which an intrarectal tumor was identified, a biopsy was taken with a histopathological report of Plasmablastic Lymphoma,