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K E Y W O R D S: antral follicle count; in-vitro ResultsThe ovarian blood flow indices VI (11.1 ± 11.6 vs. 8.6 ± 7.3%; P = 0.23), FI (38.0 ± 4.8 vs. 38.0 ± 5.5; P = 0.95) and VFI (4.2 ± 3.3 vs. 3.5 ± 3.1; P = 0.40) were similar in the OHSS group and the normal responders. While antral follicle count was significantly higher in women developing OHSS (33.0 ± 15.1) than in the control group (19.2 ± 9.9, P < 0.001), ovarian volume did not differ between the two groups (10.6 ± 3.8 vs. 8.9 ± 4.8 cm 3 , respectively, P = 0.11

Oral communication abstractsThree parents with trisomy 21 opted for termination, the baby with a postnatal diagnosis of associated total anomalous pulmonary venous return died after surgery, and 3 newborns required surgery for closing the defect (2 of them were pVDS). The rest are alive and well, at least at 1 year of life. The size of the defect was no related to the presence of associated anomalies. Intrauterine closure of the defect was observed in 10.3% of the cases. In 90.7% of the mVSD the defect closed during the first year while it was only observed in 50.6% of the pVSD (P = 0.006). Conclusions: Although prenatal diagnosis of isolated VSD is accurate, in about 10% of the cases an associated anomaly, mainly chromosomal, will be found in later studies. Particularly in cases of pVSD, a 5% risk of trisomy 21 should be discussed with parents. OC066Early Fetal Echocardiography: Results from the First trimester screening in a 3 year period K. S. Heling, R. Chaoui Prenatal diagnosis and human genetics, Berlin, GermanyObjectives: First trimester screening is widely accepted. Early detection of congenital heart defects (CHD) is also possible. Aim of the study is the use of the fetal echo in a low-risk first trimester screening group focussed on the four chamber view (4CV) and the three-vessel-trachea view (3VT). Patient and Method: This is a prospective study between september 1, 2004 and december 31, 2007. We analyzed 4800 fetuses for the first trimester screening. There were 2 examiners with level III experience. In case of an CHD we analyzed the fetal karyotype. The confirmation of the CHD was with serial ultrasound examination, third examiner, after birth or after termination of pregnancy. Results: In 73 cases we were able to find a CHD (15 different types). The major group were Atrioventricular septal defect (n = 22) or hypoplastic left heart (n = 9), rarer cases were Double outlet right ventricle (n = 3) ore Ebstein's anomaly (n = 1). In 4 pregnancies there were twins (3 with one affected fetus, 1 with two affected fetuses). Group I (NT in the normal range, n = 23 fetuses): There were 18 fetuses with normal chromosomes and 5 with an abnormal karyotype. The 4CV was suspected in 10 cases (7 additional 3VT signs) and the 3VT in 13 cases. Group II (NT > 95th, n = 7): There were 6 normal karyotypes and 1 chromosomal abnormality. The 4CV was suspected in 6 cases (2 additional 3VT signs) and the 3VT alone in 2 cases. Group III (NT > 3 mm, n = 36): There were 9 chromosomal normal fetuses and 29 chromosomal abnormal fetuses. The 4CV was suspected in 34 cases (8 additional 3VT signs) and the 3VT alone in 3 cases. In 8 cases we missed an CHD (1 transposition, 1 Fallot, 1 Ebstein, 1 Coarctatio, 1 TAPVD and 3 VSD). Conclusion: There were two major landmarks, the 4CV, which is often suspected in CHD, and the 3VT, which is especially in the group with a normal NT the leading sign for CHD. In the combination of both views it shoud be possible the detect early the major CHD. OC067Detection rate of early fetal echocardiograph...