Background: In January of 2011, the US Food and Drug Administration released a safety communication regarding the potential association between breast implants and anaplastic large cell lymphoma (ALCL). In August of 2012, the American Society of Plastic Surgeons, The Plastic Surgery Foundation, and the Food and Drug Administration signed a cooperative research and development agreement to develop a patient registry entitled the “Patient Registry and Outcomes for Breast Implants and Anaplastic Large Cell Lymphoma Etiology and Epidemiology” (PROFILE). Methods: The first report of the registry findings is presented here. Results: From August of 2012 to March of 2018, a total of 186 distinct cases of breast implant–associated ALCL (BIA-ALCL) in the United States were reported to PROFILE. At the time of this present analysis, complete detailed case report forms have been received for 89 (48%) cases. Median time from implantation of any device to BIA-ALCL diagnosis was 11.0 years (range = 2–44 years; n = 89). At the time of presentation, 96% of cases had local symptoms and 9% had concurrent systemic symptoms. The most common local symptom was a periprosthetic fluid collection seen in 86% of patients. All patients had a history of a textured device; there were no patients who had a smooth-only device history. At the time of initial case report submission, 3 deaths were reported. Conclusions: The PROFILE Registry has shown to be an essential tool in unifying the collection of data pertaining to BIA-ALCL. These data have broadened our understanding of the disease and emphasize the critical importance of detailed tracking of BIA-ALCL cases.

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Attempts for improving the synthesis procedure of catalysts for fatty acid methyl ester production have been progressing for a considerable length of time. Biodiesel lessens net carbon dioxide emissions up to 78% with reference to conventional fuel. That is the reason for the improvement of new and operative solid catalysts necessary for inexhaustible and efficient fuel production. Homogenous base catalysts for transesterification is risky in light of the fact that its produces soap as byproduct, which makes difficult issues like product separation and not temperate for industrial application. In comparison, heterogeneous process gives higher quality FAME which can be effectively isolated and facilitate costly refining operations that are not required. A focus of this review article is to study and compare various biodiesel synthesis techniques that are being researched. The catalytic strength of numerous heterogeneous solid catalysts (acid and base), specially earth and transition metal oxides were also appraised. It was observed that catalytic proficiency relied upon a few factors, for example, specific surface area, pore size, volume and active site concentration at catalyst surface. This review article will give assistance in assortment of appropriate catalysts and the ideal conditions for biodiesel generation.

Nonsurgical vulvovaginal rejuvenation (NVR) is growing in popularity as a treatment for restoration of youthful female genitalia. Numerous radiofrequency (RF) and laser devices have entered the market claiming improvement in vaginal laxity and genitourinary syndrome of menopause. There is a paucity of evidence existing concerning the effectiveness of these devices for both pre- and postmenopausal women with laxity and/or atrophy at the histologic and clinical level. Therefore, the goal of this review is to scrutinize the peer-reviewed data on NVR with RF and laser devices, identify gaps in existing literature, and propose opportunities for further investigation.

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