Oral potentially malignant disorders refer to oral mucosal disorders with increased risk for malignant transformation, primarily to oral squamous cell carcinoma (SCC). Leukoplakia and erythroplakia are the most common of these disorders, but others have been identified. Transformation rates to oral cancer vary based on multiple factors. Healthcare providers should be aware of risk factors and clinical manifestations of these disorders and should intervene early to monitor and/or treat them to reduce the potential for malignant transformation.

The development of deliberate hypotension for ENT surgery is described. A hitherto unrecorded case of paraplegia complicating hypotensive anaesthesia is reported. The use of sodium nitroprusside as a hypotensive agent is assessed. Indications and contraindications to deliberate hypotension are reviewed. Possible neurological damage is considered.

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Experience is reported of the use of immersion hypothermia on twenty-one occasions in seventeen patients in whom ethoglucid was injected by the intra-arterial route for the treatment of advanced cancer of the head and neck. The main hazards were found to be arterial hypotension occurring during the procedure and postoperative regional oedema leading to respiratory obstruction for which tracheostomy was required on eight occasions. The fall in white blood cell count was appreciably less than that reported after injection of comparable doses at normal temperature. The relief of pain after perfusion was marked.

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