Background:Cigarette smoking supposed to be a risk factor for osteoporosis. There is an inverse relationship between smoking and both bone mass and fracture risk. Tobacco smoking is the most important single source of cadmium exposure in the general population. The absorption of cadmium from the lungs is much more effective than that from the gut.Objectives:This study was designed to evaluate the effect of cigarette smoking on bone mineral density, due to cadmium toxicity.Methods:this study was carried on 100 persons, selected from AL-Azhar university hospital and divided into three groups: group I: included 40 persons with active smokers; group II: included 40 persons with passive smokers and group III included 20 nonsmokers. All persons were subjected to full history taking, thorough clinical examination, routine lab tests, serum and urinary cadmium and lead, and bone mineral density was measured by DEXA.Results:Serum and urinary cadmium and lead were statistically significantly higher in group I in comparison to groups II or III and in group II in comparison to group III. Also, there was statistically significant decrease of BMD in group I in comparison to either group II or group III and in group II in comparison to group III. There was an inverse statistically significant correlation between serum and urinary cadmium and bone mineral density.Abstract AB0984 – Table 1Comparison between studied groups as regard serum and urinary cadmium levels*=statistically significant decrease in comparison to group I or group II#=statistically significant decrease in comparison to group IConclusions:Results of the present study revealed that: there are harmful effects of smoking on the bone mineral density and it may be occurred by direct (increased blood and urinary levels of both cadmium and lead) or indirect effects (effects of both renal and liver functions) of cadmium and lead.References[1] Aoshima K, Katoh T, Kasuya M. Renal effects of environmental exposure to cadmium in middle-aged population of Jinzu River basin in Toyama, Japan: 2000–2002 study. Nippon Eiseigaku Zasshi2006;61:69–80.[2] Bernard A. Cadmium& its adverse effects on human health. Indian J Med Res2008; 128:557–64.[3] Bhattacharyya MH. Cadmium Osteotoxicity in Experimental Animals: Mechanisms and Relationship to Human Exposures. Toxicol Appl Pharmacol2009; 238(3): 258–265.[4] Hapidin H, Othman F, Soelaiman IN, Shuid AN, Luke DA, Mohamed N: Negative effects of nicotine on bone-resorbing cytokines and bone histomorphometric parameters in male rats. J Bone Miner Metab2007, 25(2):93–8.[5] Noël L, Huynh-Delerme C, Guérin T, Huet H, Frémy JM, Kolf-Clauw M. Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model. Biometals. 2006; 19(5):473–81.[6] Satarug S. Long-term exposure to cadmium in food and cigarette smoke, liver effectsand hepatocellular carcinoma. Curr Drug Metab. 2012Mar; 13(3):257–71.[7] Schutte R, Nawrot TS, Richart T, Thijs L, Vanderschueren D, Kuznetsova T, Van Hecke E, Roels ...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.