The longitudinal and transverse ultrasonic velocities and attenuations, the transport and magnetic properties, as well as the structural changes of polycrystalline La0.25Ca0.75Mn0.93Cr0.07O3 have been studied systematically. A velocity minimum and an attenuation peak for both longitudinal and transverse waves occur around the temperature Tco of charge ordering transition accompanied by the structural change from a cubic to a tetragonal phase. Near temperature TN (where the c-axis length shows a maximum), the sharp decrease of velocities for both waves and the appearance of a longitudinal attenuation peak are attributed to the antiferromagnetic transition together with the anomalous change in c-axis length of the tetragonal phase. The simultaneous occurrence of the ultrasonic, lattice, charge ordering, magnetic, and transport anomalous characteristics indicates the strong electron–phonon and spin–phonon interactions in the system.