angiogenic drugs, no significant effect of IL-8 expression was detected in either OS or PFS, using a random effect model, although with significant heterogeneity between studies.Conclusions: Our updated metanalysis confirms the role of circulating IL-8 assessment in predicting CRC prognosis, particularly in operated patients and patients undergoing anti-angiogenic treatment. These results suggest that IL-8 could be a putative target to overcome resistance to anti-angiogenesis in CRC.Legal entity responsible for the study: The authors.

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preliminary efficacy is evaluated per RECIST version 1.1 criteria. This analysis will focus on results from CCA patients enrolled in dose-escalation cohorts of the FIH study. abstracts Annals of Oncology Volume 32 -Issue S3 -2021 S187

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