Introduction: Among the depolarizing muscle relaxants, Succinylcholine is the widely used depolarizing agent until today in anaesthesia practice. Side effects like hyperkalemia, fasciculations, myalgia, increased intracranial pressure and intraocular pressure are common with the use of this drug. Pretreatment with various drugs have been proven to lessen these side effects. In our study, low dose of oral pregabalin was used as a premedication to assess its effects on the incidence and severity of fasciculations and postoperative myalgia caused by Succinylcholine administration. Materials and Methods: 60 patients of either gender undergoing elective ENT surgeries under general anaesthesia were randomly allocated to two groups of 30 each. Patients in Group PG (pregabalin group) received 75 mg of pregabalin orally 1 h prior to surgery and patients in Group CG (control group) received matching placebo. Fasciculations and myalgia grading was done by a blinded observer. Haemodynamic variables were measured at regular intervals. Results: Both groups were comparable in regard to Demographic data (p > 0.05). We didn't find any significant difference in the fasciculations incidence (p=0.702) and myalgia incidence (p=0.081) between the two groups. But the severity of fasciculations is statistically significant between the groups (< 0.001). After 24 h of surgery, severity of myalgia is mild (86.9%) in PG group when compared to CG group which was of moderate variety (80.7%) (P < 0.001). Conclusion:Low dose oral pregabalin-75 mg decreases the severity of succinylcholine-induced fasciculations and myalgia. There is not much effect on the incidence of fasciculations and myalgia in patients undergoing elective ENT surgeries.

Postoperative pain is the most annoying symptom that every patient will complain after the surgery. Relief of this pain greatly improves the patient satisfaction, compliance and recovery. Opioids and NSAIDs are the most commonly used analgesics in the postoperative period. The need for the study was to compare the efficacy of intravenous Nalbuphine over intravenous Paracetamol in the postoperative period. Materials and Methods: 60 patients who underwent elective surgeries under general anaesthesia were selected for the study. 30 patients in Group P received Inj. Paracetamol 15 mg/kg body wt. and 30 patients in Group N received Inj. Nalbuphine-0.15 mg/kg body wt over 15 min. Both the groups received the study drug half an hour before the completion of surgery. Postoperative pain scores were measured using VAS pain score and postoperative haemodynamic parameters were measured at regular intervals. The time for the first dose of rescue analgesia was noted. Side effects like sedation, nausea, vomiting, pruritus were assessed at regular intervals postoperatively until 10 hours. Results: Demographic profile were comparable between the groups. Both Nalbuphine and Paracetamol can be effectively used for treating postoperative pain. But Nalbuphine is used as safer alternative since the duration of analgesia is longer in Nalbuphine group when compared to Paracetamol group without significant side effects. Haemodynamic stability was maintained in both the groups. Conclusions: IV Nalbuphine is a better cost effective alternative to IV Paracetamol in alleviating the postoperative pain with prolonged duration of analgesia and hemodynamic stability without significant side effects.