Context and objective. Hemovigilance activities are poorly documented in sub-Saharan African countries. The present study aimed to determine the prevalence of markers of infection in Volunteer Blood Donors (VBD) and to study the place of viral hepatitis B (VHB) in the loss of status of VBD in Bangui and Bimbo. Methods. Data of first-time donors and regular VBD living in the cities of Bangui and Bimbo, who had lost their donor status in the event of positivity of a serological test between 2015 and 2019 were retrospectively examined at the National Blood Transfusion Centre. Results. 51002 VBD were involved. Their average age was 28 years (18 and 64 yrs) and males were preponderant (95%). The majority of VBD were first-time donors (58.9%). The number of donations ranges from 1 to 105. The prevalence rate of VHB had increased from 15.6% in 2015 to 20.1% in 2019, that of HIV from 6.8 to 5.2%, and of VHC from 6.1 to 3.2%. The average prevalence rate of VHB (17.2%) was three times and five times higher than HIV (5.4%), VHC (3.3%), respectively. Young ages (18-34 years) and males were significantly associated with hepatitis B and C (p< 0.05%). By contrast, regular VBD status provides a significant protective effect for all three viral pathologies. Conclusion. VHB is the first pathology to cause the loss of status of VBD in Bangui and Bimbo. Its prevalence is constantly changing. Implementation of the national VHB policy is needed. Contexte et objectif. Les activités de l’hémovigilance dans les pays d’Afrique subsaharienne sont peu documentées. La présente étude avait pour objectifs de déterminer la prévalence des marqueurs de l’infection chez les Donneurs Bénévoles de Sang (DBS) et étudier la place de l’hépatite virale B (HVB) dans la perte de statut des DBS à Bangui et Bimbo. Méthodes. Nous avons rétrospectivement examiné, les données de DBS primo-donneurs et réguliers ; du Centre National de Transfusion Sanguine, des villes de Bangui et Bimbo ayant perdu leur statut de donneur en cas de positivité d’un test sérologique, entre 2015 à 2019. Résultats. Au total, 51002 données de DBS ont été colligées. Leur âge moyen était de 28 ans (extrême 18 et 64 ans) et les hommes étaient prépondérant (95,3 %). La majorité des DBS étaient des primo donneurs (58,9 %). Le nombre de don variait de 1 à 105. Le taux de prévalence de l’HVB était passé de 15,0 % en 2015 à 20,1 % en 2019, celle du VIH de 6,8 à 5,2 % et de l’HVC de 6,1 à 3,2 %. Le taux moyen de prévalence de l’HVB (17,2%) était respectivement, trois fois et cinq fois plus élevé que celui du VIH (5,4 %) et de l’HVC (3,3 %). Le jeune âge (18 à 34 ans) et le sexe masculin étaient significativement associés à la survenue des hépatites B et C (p < 0,05). Le statut DBS régulier était en revanche protecteur pour les trois pathologies virales. Conclusion. L’HVB est la première pathologie à l'origine de la perte de statut des DBS à Bangui et Bimbo. Sa prévalence est en constante évolution. La mise en œuvre de la politique nationale de lutte contre l’HVB s’avère nécessaire.

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Background. Tuberculosis-HIV co-infection is the leading cause of death for people living with HIV (PLHIV) in the Central African Republic. The objective of this study was to determine the incidence and risk factors of TB among PLHIV in Bangui.Methods: This was a retrospective study carried out on a cohort of PLHIV followed in an HIV infection management center in Bangui. PLHIV aged 18 or older, with no history of TB, enrolled between January 1, 2017 and December 31, 2018 were included in the study. The software, Epi Info 7, made it possible to enter and analyze the data. The chi-square test was used only to compare the proportions at the 5% significance level.Results: A total of 677 patients including 618 (91.28%) on antiretroviral therapy were included in the study. The median age was 34 with extremes ranging from 18 to 57. Of the patients followed, 104 developed TB. The overall incidence of TB was 15.37 (104/677) cases per 100 PLHIV-years. This incidence was 13.10 (81/618) cases per 100 in patients on ART-years and 38.99 (23/59) cases per 100 patients on pre-ART-years. In pre-ART patients the incidence of TB was therefore almost 3 times higher than that of PLHIV on ART (p = 0.03). WHO clinical stages III and IV (p = 0.02), absence of ART (p = 0.03), poor adherence (p = 0.004) and low functional capacity (p = 0.04) were the risk factors associated with the occurrence of TB among PLHIV in Bangui.Conclusions: The high incidence of TB in our context is essentially linked to delay in diagnosis and the quality of care. Early initiation of antiretroviral therapy, systematic screening for TB in PLHIV upon entry into the active queue and better monitoring of patients on ART are strongly recommended.