The local microstructure in the heat-affected zone 1 (HAZ1) of a laser beam-welded Al-Mg-Si-Cu aluminum alloy is investigated closely. Dispersoid-free zones (DFZs), where the dispersoids of the base material (BM) are dissolved, are found in the vicinity of the fusion line (FL). They are not uniformly surrounding a grain, but oriented toward the FL. Their width can be as large as 10 m. Detailed analysis has revealed a decreased silicon concentration as well as a decreased hardness of the oriented dispersoid-free zones (ODFZs). Two mechanisms for the formation of this welding metallurgical feature are discussed.