Background: Social networking services (SNS) are a subcategory of social media that provide a useful tool for an individual’s practical life and social relations. Since the impact of SNS on students’ lives is a relatively neglected topic, we aimed to investigate the effect of social media on academic performance and self-esteem. Methods: A cross-sectional study was conducted with 373 medical students distributed across different academic years. Data was collected and analyzed using measures of central tendency to describe numerical variables, while frequencies and percentages were used for categorical variables. Pearson’s chisquared test, Pearson’s correlation coefficient, independent sample t -test, and the one-way analysis of variance (ANOVA) were used to identify relationships between the variables. All P values < 0.05 were considered significant using a 95% confidence interval and a 5% margin of error. Results: The majority of our sample believed that SNSs were useful, and 37.5% believed that social media positively affected their academic performance. However, no significant relationship was found between the time spent on social media and the students’ grade point average (GPA). Conversely, there was a significant relationship between students’ perceived addiction to social media and their self-worth, along with a positive correlation between GPA and self-esteem. Conclusion: Almost half of our participants agreed that social media is a helpful method for finding useful information. Nevertheless, excessive usage has been found to have a harmful effect on the students’ health and self-esteem.

PO.5.111 Figure 1 Active LN is associated with lowered plasma-free thiols levels. A) Plasma-free thiols levels in active LN patient's at baseline are significantly decreased compared to quiescent SLE patients and HC. B) sRAGE levels are not different between the groups. A-LN: active lupus nephritis, Q-SLE: Quiescent systemic lupus erythematosus, CTRL: healthy control Abstract PO.5.111 Figure 2 (A) Median plasma-free thiols levels during 36 months follow-up in LN patient's; (B) sRAGE levels during 36 montsh follow-up in LN patient's