Several reports have suggested that peri-operative blood transfusion promotes tumour recurrence and death after surgery for cancer. We have studied the effect of transfusion in 156 patients operated on for prostatic cancer. A retrospective review was made of the clinical, histopathological and transfusion data in their hospital records. Sixty patients received blood transfusions and 96 did not. The 5-year prostatic cancer specific survival rate was 0.56 in the transfused patients and 0.69 in the non-transfused group. The transfused patients had a higher prevalence of risk factors than did the non-transfused. When the differences in risk factors were accounted for by Cox regression analysis, peri-operative blood transfusion reduced the prostatic cancer death intensity by 36%. The study does not support the hypothesis that blood transfusion promotes recurrence following surgery for prostatic cancer.

ABSTRACT.Purpose: As part of current quality control to evaluate ophthalmic findings in the two combined central Copenhagen neonatology centres, for birth years 1999-2001, and to compare the selected sample with data of the national register for childhood visual impairment. Methods: In a prospective design to report on 372 infants mainly under regular surveillance for retinopathy of prematurity (ROP) in the stratified functional unit made up by the neonatal wards of Rigshospitalet (RH) and Hvidovre Hospital (HH). The median neonate under ophthalmic surveillance in the two wards (screening limits usually 32 weeks/1750 g) was given by gestational age (GA) and birthweight (BW) values of 27.3 weeks/907 g and 30.3 weeks/1420 g, respectively. Feedback regarding outcome was secured for those transferred to regional centres. Results: The overall frequency of ROP was 38.5% in the RH (n ¼ 252) and 10.8% in the HH sample (n ¼ 120). From a peak share above 60% in those <26 weeks/ 750 g at delivery, the incidence of ROP showed a regular decrease with decreasing immaturity. The centralized retinal ablation therapy for advanced ROP was given to a total of 29, with birth year 2001 unexpectedly showing a peak of 17 cases. Seven of the 29 children treated are now in the register for visually impaired, mainly due to low vision. Fourteen of the 29 had been very small for gestational age. Conclusions: Supported also by recent regional Danish data, the apparent progress in the fight against ROP over many years seems to have come to a halt. Except for the continued increased survival of extremely preterm babies we have no obvious neonatological indications to explain the suggested 'adverse' trend.

Perineal seeding of cancer of the prostate is a rare complication after transperineal prostatic biopsy. In the present case the biopsy responsible for the seeding was false-negative, but microscopy of the perineal lesion showed a differentiated adenocarcinoma.

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