Injuries to immature permanent teeth may cause pulp necrosis. Conventional treatment for such teeth is root canal treatment and apexification, but recently a new treatment option of revascularization has been introduced, also known as regenerative endodontic treatment. This study compared the treatment outcome of apexification and pulp revascularization in immature necrotic teeth. All the patients were treated, and data were acquired from the dental outpatient department of Shahida Islam Medical and Dental College, Lodhran, between November 15, 2021, to November 14, 2022, duration. To complete this research, Randomized Controlled Clinical Trial was used as a study design to collect the patients, later divided into two groups. Means age of all the patients in this study was 11.41 ± 4.20 years; the mean age of the patients in Group A=11.50 ± 4.24 years and Group B=11.32 ± 4.26 years. The success rate in Group A= 60 (87.32%) was lower than that of Group B= 67 (97.04%). The results of this study revealed that pulp revascularization has a higher success rate than apexification by mineral trioxide aggregate.

The study aimed to assess occlusal reduction's effect on postoperative pain in multiple-visit root canal treatment. This randomized control trial was conducted at the Operative Dentistry & Endodontics Department, Baqai Dental College Karachi, from January 2021 to January 2022. A total of 110 patients fulfilling the inclusion criteria were included in the study. The patient was divided into two groups, Group A, occlusal reduction (OR) and Group B, no occlusal reduction (NOR). In group A, all occlusal contacts on the functional and non-functional cuspsand the marginal ridges were reduced by 1 mm by a diamond bur in a high-speed handpiece and confirmed with articulating paper. No occlusal reduction was performed in group B patients. Patients were recalled after 24 hours and 7 days, and their pain level was recorded on VAS; at the same appointment, the root canal was completed, and the tooth was restored permanently. Pain level on the 7th day was taken as the study's primary endpoint. The meanage of patients was 37.41±10.635, with a minimum age of 19 and a maximum of 59 years old. Female patients were 56% and 44%, male. There were two study groups' OR 50% and NOR 50%. The tooth type included were 40% anterior and 60% posterior. Group A patients had reduced pain levels after 24 hours, with a significant difference of P=0.014 compared to group B patients. After 7 days of treatment, no significant difference was found in postoperative pain between both groups with P=0.533. Thus, it can be concluded from the study that the occlusive reduction may not be effective in reducing pain at the 7th postoperative days of multiple visit root canal treatment. Although a significant difference in pain levels was identified after 24 hours of therapy, patients in the occlusion reduction group reported less discomfort than those in the control group.

Objective: To determine the frequency of two canals in mandibular central incisors using a radiographic technique in a sample representing Karachi Pakistan. Study Design: Cross-sectional in Vitro study. Setting: Hamdard University Dental Hospital. Period: January, 2022 to July, 2022. Material & Methods: According to inclusion criteria 187 extracted mandibular central incisors were collected, flushed under running tap water. 10% formalin was used as storage media afterwards. The attached periodontal tissues and calculus remaining after extraction were removed using a 1/2 Gracey Curette. Number 2 round bur was used in a high speed hand piece to initiate access chamber opening of the pulp chamber. Irrigation was done with 2.5% sodium hypochlorite to make the pulp chamber clearly visible. Detection and negotiation of second canal were performed by using Dental Operating Microscope. No. 15 K-files were introduced into the main canals. Two peri-apical radiographs were exposed at different angulations using DIGORA OPTIME for confirmation. Data was analyzed by using SPSS version 23. Results: Mean age of the patients included in the study were 37.12±12.81 years. According to gender distribution there were 101 (54%) males and 86 (46%) females. Outcome concludes that in mandibular central incisors frequency of two canals was 28.3 %. Conclusion: Presence of two canals in mandibular central incisors among Pakistani population in our study was 28.3%. When endodontic therapy is commenced on these teeth, dentist must consider the possibility of existence of second canal and exercise caution.