There is a great evidence for the inheritance of the serum Gm system; the inheritance of the Inv factors, on the other hand, has not yet been confirmed to such a degree [2] though, in a broader sense, both these gamma-globulin serum systems are equally significant. The occurrence and inheritance of Inv(a) factor in inhabitants of Leipzig and Prague was reported in our previous paper [l]. The results of familial examinations performed in further inhabitants of Leipzig and in the Slovak population from Prelov region are presented in this paper. The occurrence of Inv(a) in healthy members of the examined families was determined by usual technique [3]. Two anti-Inv(a) sera were obtained from healthy personsblood donors. Examinations were performed in 82 families from Leipzig yielding 143 children, and in 23 families from Pregov and surroundings having 82 children.Results of our investigations are given in Table I and 11. A low or negative incidence of parental Inv(a+) x Inv(a+) combination results from the low frequency of Inv(a) factor in examined population [l] and in the second case also from the low total number of examined families. The number of observed Inv(a) combinations in parents sufficiently correlates with theoretical presumptions (p = 0.7 to 0.5 for Leipzig and 0.5 t o 0.3 for Pregov); the material under investigation therefore corresponds well to the requirements of panmixia.Results of investigations of the inheritance of Inv(a) factor performed in the children of assayed families (Table 11) correlate sufficiently with the numbers calculated on the basis of gene frequency [l].Taking the total number of families assayed in our previous [l] and present investigation, the incidence of the Inv(a) factor was
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.